High intensity exercise decreases global brain glucose uptake in humans
High intensity exercise decreases global brain glucose uptake in humans
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DOI：
10.1113/jphysiol.2005.091355
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发表时间：
2005-10-01
影响因子：
5.5
通讯作者：
Knuuti, J
中科院分区：
文献类型：
--
作者：
Kemppainen, J;Aalto, S;Knuuti, J
生理激活增加大脑局部的葡萄糖摄取。然而，尚不清楚高强度运动如何影响局部和整体大脑葡萄糖摄取。运动强度和运动能力对脑葡萄糖摄取的影响直接使用正电子发射断层扫描（PET）和[F-18]氟脱氧葡萄糖（[F-18]FDG）测量。14名健康的右利手男性进行了研究后，35分钟的自行车运动，运动强度分别为30，55和75%的V-O2 max在三个独立的日子。[F-18]FDG在运动开始后10分钟注射。此后，继续运动25分钟。运动结束后进行脑部PET扫描。区域葡萄糖代谢率（rGMR）下降，在所有测量的皮质区域的运动强度增加。在大脑中，最高和最低运动强度之间的平均下降幅度为32%（38.6 +/- 4.6 vs 26.1 +/- 5.0 μ mol（100 g）（-1）min（-1），P < 0.001）。运动期间乳酸的可用性往往与观察到的脑葡萄糖摄取呈负相关。此外，前扣带皮层背侧部分葡萄糖摄取的减少（37%对20%，在V-O2 max的30%和75%之间P < 0.05）在运动能力较高的受试者中显著更明显。这些结果表明，脑葡萄糖摄取随着运动强度的增加而减少。因此，除了葡萄糖以外的底物，最可能是乳酸盐，被大脑利用，以补偿在高强度运动期间维持神经元活性所需的增加的能量。此外，似乎运动训练可能与额叶皮质区域局部的适应性代谢变化有关。
Physiological activation increases glucose uptake locally in the brain. However, it is not known how high intensity exercise affects regional and global brain glucose uptake. The effect of exercise intensity and exercise capacity on brain glucose uptake was directly measured using positron emission tomography (PET) and [F-18]fluoro-deoxy-glucose ([F-18]FDG). Fourteen healthy, right-handed men were studied after 35 min of bicycle exercise at exercise intensities corresponding to 30, 55 and 75% of V-O2max on three separate days. [F-18]FDG was injected 10 min after the start of the exercise. Thereafter exercise was continued for another 25 min. PET scanning of the brain was conducted after completion of the exercise. Regional glucose metabolic rate (rGMR) decreased in all measured cortical regions as exercise intensity increased. The mean decrease between the highest and lowest exercise intensity was 32% globally in the brain (38.6 +/- 4.6 versus 26.1 +/- 5.0 mu mol (100 g)(-1) min(-1), P < 0.001). Lactate availability during exercise tended to correlate negatively with the observed brain glucose uptake. In addition, the decrease in glucose uptake in the dorsal part of the anterior cingulate cortex (37% versus 20%, P < 0.05 between 30% and 75% of V-O2max) was significantly more pronounced in subjects with higher exercise capacity. These results demonstrate that brain glucose uptake decreases with increase in exercise intensity. Therefore substrates other than glucose, most likely lactate, are utilized by the brain in order to compensate the increased energy needed to maintain neuronal activity during high intensity exercise. Moreover, it seems that exercise training could be related to adaptive metabolic changes locally in the frontal cortical regions.