Disparate effects of depletion of CD1d-reactive T cells during early versus late stages of disease in a genetically susceptible model of lupus.
Disparate effects of depletion of CD1d-reactive T cells during early versus late stages of disease in a genetically susceptible model of lupus.
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DOI：
10.1177/0961203311428459
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发表时间：
2012-04
期刊：
影响因子：
2.6
通讯作者：
Singh RR
中科院分区：
文献类型：
--
作者：
Jacinto J;Kim PJ;Singh RR
Some T cells react with lipid antigens bound to antigen-presenting molecule CD1d. Numbers and functions of a subset of such lipid-reactive T cells are reduced in patients with systemic lupus erythematosus (SLE) and their relatives, as well as in genetically susceptible and chemically induced animal models of lupus-like disease. We have reported that the germline deletion of CD1d exacerbates lupus, suggesting a protective role of these cells in the development of lupus. The use of a knockout mouse model in this study, however, did not allow examination of the role of these cells at different stages of disease. Here, we describe an approach to deplete CD1d-dependent T cells, which allowed us to investigate the role of these cells at different stages of disease in genetically lupus-prone NZB/NZW F1 (BWF1) mice. Repeated intravenous injections of large numbers of CD1d-transfected cells resulted in ~50–75% reduction in these cells, as defined by the expression of CD4, NK1.1 and CD122, and lack of expression of CD62 ligand. TCR γδ +NK1.1+ cells were also reduced in the recipients of CD1d-transfected cells as compared with control recipients. Such depletion of CD1d-reactive T cells in preclinical BWF1 mice resulted in disease acceleration with a significant increase in proteinuria and mortality. In older BWF1 mice having advanced nephritis, however, such depletion of CD1d-reactive T cells resulted in some disease improvement. Taken together, these data as well as our published studies suggest that CD1d-reactive T cells protect against the development of lupus in animal models. However, these cells appear to be unable to suppress established lupus nephritis in these animals, and might even play a disease aggravating role in late stages of disease.
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影响因子：
8.6
作者：
van der Vliet, HJJ;von Blomberg, BME;Pinedo, HM
通讯作者：
Pinedo, HM
DOI：
10.1084/jem.20020223
发表时间：
2002-09-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Fan GC;Singh RR
通讯作者：
Singh RR
影响因子：
5.5
作者：
Cho, Young-Nan;Kee, Seung-Jung;Park, Yong-Wook
通讯作者：
Park, Yong-Wook
DOI：
10.1084/jem.177.1.155
发表时间：
1993-01-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Takeda K;Dennert G
通讯作者：
Dennert G
影响因子：
5.4
作者：
Yang, JQ;Chun, T;Singh, RR
通讯作者：
Singh, RR