VOLTAGE-DEPENDENT CALCIUM CHANNELS IN GLIAL-CELLS
VOLTAGE-DEPENDENT CALCIUM CHANNELS IN GLIAL-CELLS
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DOI：
10.1126/science.6095454
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
MACVICAR, BA
中科院分区：
文献类型：
--
作者：
MACVICAR, BA
神经胶质细胞的电生理特性进行了研究，在原代培养中的存在下，四乙基铵和Ba 2+，治疗，降低K+渗透性的膜和增强电流通过电压依赖性钙离子通道。在这些条件下，神经胶质细胞表现出自发的动作电位和动作电位诱发的电流注入。这些反应似乎代表通过Ca 2+通道进入Ba 2+，因为它们对河豚毒素具有抗性，但被Mn 2+或Cd 2+阻断。
The electrophysiological properties of glial cells were examined in primary culture in the presence of tetraethylammonium and Ba2+, a treatment that reduces K+ permeability of the membrane and enhances currents through voltage-dependent Ca2+ channels. Under these conditions, glial cells showed both spontaneous action potentials and action potentials evoked by the injections of current. These responses appear to represent entry of Ba2+ through Ca2+ channels because they were resistant to tetrodotoxin but were blocked by Mn2+ or Cd2+.