Gas-Shearing Fabrication of Multicompartmental Microspheres: A One-Step and Oil-Free Approach
Gas-Shearing Fabrication of Multicompartmental Microspheres: A One-Step and Oil-Free Approach
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多室微球的气体剪切制造：一种一步法、无油方法
DOI：
10.1002/advs.201802342
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发表时间：
2019-05-03
期刊：
影响因子：
15.1
通讯作者：
De Smedt, Stefaan C.
中科院分区：
文献类型：
--
作者：
Tang, Guosheng;Xiong, Ranhua;De Smedt, Stefaan C.
多室微粒子（MCM）由于可以在单个粒子的分离相中携带多种物质而在生物医学工程和材料科学中引起了相当大的关注。然而，在微米和纳米尺度上稳定地制造单分散的、高度隔室的MCM仍然具有挑战性。在这里，一个简单的一步和无油的过程，基于气流辅助形成的微滴（“气体剪切”），建立了单分散MCMs的规模化生产。通过改变喷射器装置中的针系统和气流的配置，无油气体剪切过程容易地允许设计由两个、四个、六个甚至八个隔室组成的微粒，并精确控制每个隔室的性质。由于不使用油和表面活性剂，气体剪切方法具有高度的细胞相容性。这种MCMs的多用途应用通过生产磁性microrobot和用于细胞共培养的生物相容性载体来证明。这项研究表明，无油气体剪切策略是一种可靠的，可扩展的，生物友好的生产MCMs的方法，可能成为生物医学应用的有吸引力的材料。
Multicompartmental microparticles (MCMs) have attracted considerable attention in biomedical engineering and materials sciences, as they can carry multiple materials in the separated phases of a single particle. However, the robust fabrication of monodisperse, highly compartmental MCMs at the micro- and nanoscales remains challenging. Here, a simple one-step and oil-free process, based on the gas-flow-assisted formation of microdroplets ("gas-shearing"), is established for the scalable production of monodisperse MCMs. By changing the configuration of the needle system and gas flow in the spray ejector device, the oil-free gas-shearing process easily allows the design of microparticles consisting of two, four, six, and even eight compartments with a precise control over the properties of each compartment. As oils and surfactants are not used, the gas-shearing method is highly cytocompatible. The versatile applications of such MCMs are demonstrated by producing a magnetic microrobot and a biocompatible carrier for the coculturing of cells. This research suggests that the oil-free gas-shearing strategy is a reliable, scalable, and biofriendly process for producing MCMs that may become attractive materials for biomedical applications.