Increase of prevalence of craniosynostosis
Increase of prevalence of craniosynostosis
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DOI：
10.1016/j.jcms.2016.07.007
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发表时间：
2016-09-01
影响因子：
3.1
通讯作者：
Mathijssen, Irene
中科院分区：
文献类型：
--
作者：
Cornelissen, Martijn;den Ottelander, Bianca;Mathijssen, Irene
简介：颅缝早闭代表颅缝过早闭合。患病率约为每10 000名活产婴儿中有3.1-6.4人患病，据报告，这一比例正在上升。这项流行病学研究的目的是通过准确描述患病率，探索区域差异和随时间的变化，提供对这一上升的洞察力。方法：咨询荷兰腭裂和颅面畸形协会，以确定2008年至2013年出生的颅缝早闭患者。使用治疗这些患者的所有医院提供的数据验证数据。收集以下数据：出生日期、性别、诊断和邮政编码。从1997年到2007年以前报告的数据被纳入到评估患病率的变化多年来。结果：在2008年和2013年之间，759例颅缝早闭患者出生在荷兰。颅缝早闭症的患病率为每10 000例活产7.2例。骶管骨性结合是最常见的形式（44%）。Poisson回归分析显示，从1997年到2013年，总颅缝早闭（+12.5%）、矢状面（+11.7%）和额位（+20.5%）的患病率显著增加。结论：在荷兰，颅缝早闭的患病率为7.2/10.000活产儿童。从1997年到2013年，全颅缝早闭、矢状缝和额颞缝早闭的患病率显著上升，但没有明显的原因。(C)2016年欧洲颅颌面外科协会。由爱思唯尔有限公司出版。保留所有权利。
Introduction: Craniosynostosis represents premature closure of cranial sutures. Prevalence is approximately 3.1-6.4 in 10.000 live births, which is reportedly rising. This epidemiologic study aims to provide insight into this rise through an accurate description of the prevalence, exploring regional variation and change over time.Methods: The Dutch Association for Cleft Palate and Craniofacial Anomalies was consulted to identify patients with craniosynostosis born between 2008 and 2013. Data were verified using data provided by all hospitals that treated these patients. The following data were collected: date of birth, gender, diagnosis and postal code. Previously reported data from 1997 until 2007 were included to assess for change in prevalence over the years.Results: Between 2008 and 2013 759 patients with craniosynostosis were born in the Netherlands. Prevalence of craniosynostosis was 7.2 per 10.000 live births. Sagittal synostosis was the most common form (44%). Poisson regression analysis showed a significant mean annual increase of prevalence of total craniosynostosis (+12.5%), sagittal (+11.7%) and metopic (+20.5%) synostosis from 1997 to 2013.Conclusion: The prevalence of craniosynostosis is 7.2 per 10.000 live born children in the Netherlands. Prevalence of total craniosynostosis, sagittal and metopic suture synostosis has risen significantly from 1997 until 2013, without obvious cause. (C) 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.