Clinical Significance of Lymph Node Ratio in Stage III Colorectal Cancer.
Clinical Significance of Lymph Node Ratio in Stage III Colorectal Cancer.
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DOI：
10.3393/jksc.2011.27.5.260
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发表时间：
2011-10
期刊：
影响因子：
--
通讯作者：
An CH
中科院分区：
文献类型：
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作者：
Park YH;Lee JI;Park JK;Jo HJ;Kang WK;An CH
近年来的文献表明，淋巴结比率在预测除结直肠癌以外的其他恶性肿瘤的预后方面优于淋巴结转移的绝对数量上级。本研究的目的是评估淋巴结比率（LNR）在III期结直肠癌患者中的预后意义。我们纳入了186例III期结直肠癌患者，他们在一家医院接受了10年以上的根治性切除术。LNR的临界点选择为0.07，因为在该LNR下存在显著的生存差异。采用Kaplan-Meier和考克斯比例风险模型，根据LNR评估预后效果。LNR > 0.07组总生存期明显长于LNR ≤ 7组（P = 0.008）。尤其是根据LNR判断的N1组（LN < 4）患者的生存率有差异（LNR > 0.07组N1患者的5年生存率较低，P = 0.025），而根据LNR判断的N2组（LN ≥ 4）患者的生存率无差异。多因素分析显示LNR是独立的预后因素。LNR可以被认为是III期结直肠癌患者预后分层的一种更准确和有效的方式。
Recent literature has shown that lymph node ratio is superior to the absolute number of metastatic lymph nodes in predicting the prognosis in several malignances other than colorectal cancer. The aim of this study was to evaluate the prognostic significance of the lymph node ratio (LNR) in patients with stage III colorectal cancer. We included 186 stage III colorectal cancer patients who underwent a curative resection over a 10-year period in one hospital. The cutoff point of LNR was chosen as 0.07 because there was significant survival difference at that LNR. The Kaplan-Meier and the Cox proportional hazard models were used to evaluate the prognostic effect according to LNR. There was statistically significant longer overall survival in the group of LNR > 0.07 than in the group of LNR ≤ 7 (P = 0.008). Especially, there was a survival difference for the N1 patients group (LN < 4) according to LNR (5-year survival of N1 patients was lower in the group of LNR > 0.07, P = 0.025), but there was no survival difference for the N2 group (4 ≥ LN) according to LNR. The multivariate analysis showed that the LNR is an independent prognostic factor. LNR can be considered as a more accurate and potent modality for prognostic stratifications in patients with stage III colorectal cancer.