Validation and calibration of the patient health questionnaire (PHQ-9) in Argentina
Validation and calibration of the patient health questionnaire (PHQ-9) in Argentina
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DOI：
10.1186/s12888-019-2262-9
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发表时间：
2019-09-18
期刊：
影响因子：
4.4
通讯作者：
Irazola, Vilma
中科院分区：
文献类型：
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作者：
Urtasun, Maria;Manuel Daray, Federico;Irazola, Vilma
背景患者健康问卷-9（PHQ-9）是一个评估抑郁症状存在和严重程度的简单工具。本研究旨在验证和校准PHQ-9，以确定阿根廷不同程度抑郁症的适当临界点。方法采用横断面研究方法，对不同抑郁程度的成人门诊患者进行调查。所有完成PHQ-9的患者由经过培训的临床医生进行进一步访谈，包括国际神经精神访谈（MINI）和贝克抑郁量表-II（BDI-II）。进行了信度和效度检验，包括受试者工作曲线分析。结果共纳入169例患者，平均年龄47.4岁（SD = 14.8），其中女性102例（60.4%）。本地PHQ-9具有较高的内部一致性（Cronbach's alpha = 0.87）和与BDI-II量表的良好收敛效度[Pearson's相关= 0.88（p < 0.01）]。对于根据MINI诊断重度抑郁发作（MDE），PHQ-9 >= 8是发现的最佳截断点（灵敏度88.2%，特异性86.6%，PPV 90.91%）。本地版本的PHQ-9表现出良好的能力，区分抑郁症的严重程度类别，根据BDI-II量表。最佳分界点分别为轻度6-8分、中度9-14分、重度15分以上。结论阿根廷版的PHQ-9问卷在抑郁症状的筛查和严重程度评估中显示出可接受的效度和信度。
Background The Patient Health Questionnaire-9 (PHQ-9) is a brief tool to assess the presence and severity of depressive symptoms. This study aimed to validate and calibrate the PHQ-9 to determine appropriate cut-off points for different degrees of severity of depression in Argentina. Methods We conducted a cross-sectional study on an intentional sample of adult ambulatory care patients with different degrees of severity of depression. All patients who completed the PHQ-9 were further interviewed by a trained clinician with the Mini International Neuropsychiatric Interview (MINI) and the Beck Depression Inventory-II (BDI-II). Reliability and validity tests, including receiver operating curve analysis, were performed. Results One hundred sixty-nine patients were recruited with a mean age of 47.4 years (SD = 14.8), of whom 102 were females (60.4%). The local PHQ-9 had high internal consistency (Cronbach's alpha = 0.87) and satisfactory convergent validity with the BDI-II scale [Pearson's correlation = 0.88 (p < 0.01)]. For the diagnosis of Major Depressive Episode (MDE) according to the MINI, a PHQ-9 >= 8 was the optimal cut-off point found (sensitivity 88.2%, specificity 86.6%, PPV 90.91%). The local version of PHQ-9 showed good ability to discriminate among depression severity categories according to the BDI-II scale. The best cut off points were 6-8 for mild cases, 9-14 for moderate and 15 or more for severe depressive symptoms respectively. Conclusions The Argentine version of the PHQ-9 questionnaire has shown acceptable validity and reliability for both screening and severity assessment of depressive symptoms.