Comparison of the Effect of Dexmedetomidine and Propofol on Duration of Starting Tremor after Drug discontinuation in Parkinson's Patients under Deep Brain stimulation
Comparison of the Effect of Dexmedetomidine and Propofol on Duration of Starting Tremor after Drug discontinuation in Parkinson's Patients under Deep Brain stimulation
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DOI：
10.5539/jmbr.v8n1p1
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发表时间：
2018-01-01
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影响因子：
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通讯作者：
Shabanpour, Yalda
中科院分区：
文献类型：
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作者：
Behnaz, Faranak;Ghasemi, Mahshid;Shabanpour, Yalda
本研究的目的是比较右美托咪定和丙泊酚对帕金森病患者在脑深部电刺激下停药后开始震颤持续时间的影响。为了达到研究目标，2016年在Taleghani医院麻醉学助理教授的指导下，将28名接受脑深部电刺激的帕金森病患者随机分为两组，包括右美托咪定和丙泊酚。在实施阶段。使用了以下药物：右美托咪定（Precedex）剂量为0.2-0.4 mu/kg/h，丙泊酚剂量为20-30 mg推注，然后以10-20 mu/kg/min输注，BIS控制并保持在65 - 85之间，RAMSY镇静评分等于3。针刺部位和头部头皮用利多卡因麻醉。在手术结束时记录局部麻醉药物的总剂量。停药和震颤开始之间的间隔时间以及苏醒时间记录为放松和患者能够配合进行神经系统检查之间的时间。记录手术期间的所有事件和并发症以及疼痛和躁动的主诉。此外，还对以下病例进行了研究：术后疼痛、生命体征、血流动力学变化、患者在PACU中2小时的呼吸和警觉状态。每隔30分钟使用VAS（0：无痛，10：最大疼痛）测量患者的疼痛。采用独立t检验和Mann-Whitney检验进行数据分析。结果显示，两组患者的震颤时间和合作时间变量之间存在显著差异。平均比较显示，丙泊酚组的平均震颤时间和合作时间均高于右美托咪定（DEX）组。其他结果显示，两组BIS无显著差异。结果还显示，两组的VAS和外科医生满意度变量之间存在显著差异。异丙酚组VAS评分明显高于DEX组。DEX组的平均外科医生满意度显著高于丙泊酚组。一般来说，可以说，对于帕金森病患者，右美托咪定是比丙泊酚更好的脑深部电刺激上级药物。
The purpose of this study was to compare the effects of Dexmedetomidine and Propofol on the duration of starting tremor after drug discontinuation in patients with Parkinson's disease under deep brain stimulation. In order to reach the research goals, 28 individuals with Parkinson's disease under deep brain stimulation were randomly assigned into two groups including Dexmedetomidine and Propofol that referring to Assistant Professor of Anesthesiology Taleghani Hospital in 2016. In the implementation phase. The following drugs were used: Dexmedetomidine (Precedex) with dose of 0.2-0.4 mu/kg/h and Propofol with doses of 20-30 mg bolus, and then 10-20 mu/kg/min infusion, with a control and preservation of BIS between 65 and 85, and also, RAMSY Sedation Score equal to 3. Locus of pin and the head scalp were anaesthetized with lidocaine drug. The total dose of local anaesthetic drugs was recorded at the end of the procedure. The interval time between drug discontinuation and start of tremor, and also, the time of emergence, was recorded as the time between relaxation and when the patient is able to cooperate for a neurological examination All of the events during the operation and complications and complains of pain and restlessness were recorded. Moreover, the following cases were investigated Post-operative pain, vital signs, and hemodynamic changes, respiratory and alert status of patients for 2 hours in PACU. Patients' pain was measured using VAS (0: painless, 10: maximum pain) at intervals of 30 minutes. Independent t-test and Mann-Whitney test were used for data analysis. Findings showed that there was a significant difference between time to tremor and time to cooperation variables in the two groups. Mean comparison showed that the mean time to tremor and time to cooperation in the Propofol group was higher than the Dexmedetomidine (DEX) group. Other findings showed that there was no significant difference between BIS in the two groups. The results also showed that there was a significant difference between VAS and surgeon satisfaction variables in the two groups. Mean VAS in Propofol group was significantly higher than DEX group. Mean of surgeon satisfaction in the DEX group was significantly higher than Propofol group. In general, it can be said that patients with Parkinson's disease, Dexmedetomidine is superior drug to Propofol to deep brain stimulation.