Efferent phrenic nerve and respiratory neuron activities in the developing kitten: spontaneous discharges and hypoxic responses.
Efferent phrenic nerve and respiratory neuron activities in the developing kitten: spontaneous discharges and hypoxic responses.
复制标题
发育中小猫的传出膈神经和呼吸神经元活动：自发放电和缺氧反应。
DOI：
10.1016/0006-8993(90)90699-c
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发表时间：
1990
期刊：
影响因子：
2.9
通讯作者：
Gandhi,MR
中科院分区：
文献类型：
--
作者：
Sica,AL;Gandhi,MR
本实验观察了麻醉和去脊椎动物幼猫(22-150日龄)在常压高氧和低氧条件下，传出膈神经和延髓呼吸神经元放电的年龄相关性变化。在39日龄以下的动物，高氧期间的膈功率谱以中频段(20-50赫兹)的成分为主，而至少39日龄的动物的频谱以高频段(50-100赫兹)的成分为主。这种高频振荡也在至少43天大的动物的一些吸气神经元的功率谱中观察到。在低氧条件下，39日龄及以下动物的膈神经放电幅度先是易化，而后逐渐减弱(即双相反应)。然而，在年龄超过39天的动物中，低氧引起了持续的膈神经放电幅度的易化。相反，没有观察到神经元放电对低氧的反应模式随年龄的变化；相反，大多数神经元的反应包括放电频率的减少或完全取消放电。
Efferent phrenic nerve and medullary respiratory neuron discharges were examined for age-dependent changes of activities during normocapnic hyperoxia and hypoxia in anesthetized and decebrate kittens (22–150 days old). In animals less than 39 days of age, phrenic power spectra during hyperoxia were dominated by components in the medium-frequency band (20–50 Hz), whereas spectra of animals of at least 39 days of age were dominated by components in the high-frequency band (50–100 Hz). Such high-frequency oscillations were also observed in the power spectra of some inspiratory neurons in animals of at least 43 days old. In hypoxia, the amplitude of phrenic discharge exhibited an initial facilitation folloed by a diminution (i.e. biphasic response) in animals 39 days old or younger. In animals older than 39 days, however, hypoxia elicited a sustained facilitation of phrenic discharge amplitude. In contrast, no such age-dependent change in response pattern to hypoxia was observed for neuronal discharges; rather, responses of most neurons consisted of either decreases of discharge frequency, or complete abolishment of discharges.