Computational modeling of arterial wall growth - Attempts towards patient-specific simulations based on computer tomography
Computational modeling of arterial wall growth - Attempts towards patient-specific simulations based on computer tomography
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DOI：
10.1007/s10237-006-0062-x
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发表时间：
2007-09-01
影响因子：
3.5
通讯作者：
Menzel, A.
中科院分区：
文献类型：
--
作者：
Kuhl, E.;Maas, R.;Menzel, A.
本文记录了我们首次使用应力诱导的动脉壁生长和与动脉粥样硬化相关的支架内再狭窄的计算模型的经验。基本的理论框架是由有限增长运动学和开放系统热力学相结合提供的。计算模拟嵌入在有限元方法中，其中增长基本上由单个标量值增长因子作为积分点级别的内部变量引入。该模型的概念简单性使其能够直接实现为标准的商业有限元代码。对应力引起的动脉壁厚度变化在球囊血管成形术或支架植入反应的定性研究被提出，以说明建议的生长模型的特点。本文讨论了基于计算机断层扫描数据生成的真实动脉形态的患者特异性模拟的首次尝试。
The present manuscript documents our first experiences with a computational model for stress-induced arterial wall growth and in-stent restenosis related to atherosclerosis. The underlying theoretical framework is provided by the kinematics of finite growth combined with open system thermodynamics. The computational simulation is embedded in a finite element approach in which growth is essentially captured by a single scalar-valued growth factor introduced as internal variable on the integration point level. The conceptual simplicity of the model enables its straightforward implementation into standard commercial finite element codes. Qualitative studies of stress-induced changes of the arterial wall thickness in response to balloon angioplasty or stenting are presented to illustrate the features of the suggested growth model. First attempts towards a patient-specific simulation based on realistic artery morphologies generated from computer tomography data are discussed.