Endometrial CD56+natural killer cells in women with recurrent miscarriage: a histomorphometric study
Endometrial CD56+natural killer cells in women with recurrent miscarriage: a histomorphometric study
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DOI：
10.1093/humrep/14.11.2727
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发表时间：
1999-11-01
影响因子：
6.1
通讯作者：
Regan, L
中科院分区：
文献类型：
--
作者：
Clifford, K;Flanagan, AM;Regan, L
比较了复发性流产妇女和正常妇女黄体期子宫内膜中的自然杀伤（NK）细胞。使用抗生物素蛋白-生物素复合物方法，使用抗CD 56单克隆抗体标记冷冻切片，并进行形态测定研究。CD 56+细胞的平均数量增加记录在子宫内膜的妇女复发性早期流产。这些发现表明NK细胞可能在复发性早期妊娠丢失的发病机制中发挥作用。
Endometrial natural killer (NK) cells were compared in luteal-phase endometrial samples from women,vith recurrent miscarriage and from normal subjects. Cryostat sections were labelled using a monoclonal antibody to CD56 using an avidin-biotin complex method and a morphometric study performed. Increased mean numbers of CD56+ cells were documented in the endometrium of women with recurrent early miscarriage only. These findings suggest a possible role for NK cells in the pathogenesis of recurrent early pregnancy loss.