BRCA1 Is a Selective Co-activator of 14-3-3s Gene Transcription in Mouse
BRCA1 Is a Selective Co-activator of 14-3-3s Gene Transcription in Mouse
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BRCA1 是小鼠 14-3-3s 基因转录的选择性共激活剂
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
E. Liu
中科院分区：
文献类型：
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作者：
O. Aprelikova;A. Pace;B. Fang;B. Koller;E. Liu
BRCA 1基因是乳腺癌和卵巢癌的抑癌基因，可能参与DNA修复和转录。为了研究BRCA 1在转录调控中的作用，我们利用微阵列技术分析了BRCA 1缺陷小鼠胚胎干细胞的基因表达谱。我们发现BRCA 1的缺失与几组基因表达的降低相关，包括应激反应基因、细胞骨架基因以及参与蛋白质合成和降解的基因。以往的研究表明BRCA 1是p53蛋白的转录辅激活因子，但在BRCA 1基因敲除的细胞中，大多数p53靶基因的表达水平与野生型细胞相同。在BRCA 1缺失的情况下，p53靶基因下调的仅有14-3-3
BRCA1 gene is a tumor suppressor for breast andovarian cancers with the putative role in DNA repairand transcription. To characterize the role of BRCA1 intranscriptional regulation, we analyzed gene expressionprofiles of mouse embryonic stem cells deficient inBRCA1 using microarray technology. We found that lossof BRCA1 correlated with decreased expression of sev-eral groups of genes including stress response genes,cytoskeleton genes, and genes involved in protein syn-thesis and degradation. Previous study showed thatBRCA1 is a transcriptional co-activator of p53 protein;however the majority of p53 target genes remained atthe same expression levels in BRCA1 knockout cells asin the wild type cells. The only p53 target gene down-regulated with the loss of BRCA1 was 14-3-3
影响因子：
16
作者：
Xu, XL;Weaver, Z;Deng, CX
通讯作者：
Deng, CX