Catalytic, Asymmetric Total Synthesis of (+)-α-, (+)-β-, (+)-γ-, and (-)-δ-Lycorane.
Catalytic, Asymmetric Total Synthesis of (+)-α-, (+)-β-, (+)-γ-, and (-)-δ-Lycorane.
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DOI：
10.1021/acs.orglett.2c00905
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发表时间：
2022-04
期刊：
影响因子：
5.2
通讯作者：
Tian-Yuan Zhang;Lu-Yue Zhang;Xiaomei Liang;Kun Wei;Yu-Rong Yang
中科院分区：
文献类型：
--
作者：
Tian-Yuan Zhang;Lu-Yue Zhang;Xiaomei Liang;Kun Wei;Yu-Rong Yang
The first collectively asymmetric total synthesis of all members of lycorane, including (+)-α, (+)-β, (+)-γ, and (-)-δ, in a catalytic manner has been achieved. The cornerstone of this synthesis features an asymmetric, stereodivergent Ir/amine dual catalytic α-allylation of 2-phthalimidoacetaldehyde.
