Vitamin D insufficiency in preadolescent African-American children
Vitamin D insufficiency in preadolescent African-American children
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DOI：
10.1177/000992280504400806
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发表时间：
2005-10-01
影响因子：
1.6
通讯作者：
Greenspan, SL
中科院分区：
文献类型：
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作者：
Rajakumar, K;Fernstrom, JD;Greenspan, SL
为了确定居住在宾夕法尼亚州匹兹堡的6-10岁青春期前非裔美国儿童维生素D缺乏的比例，并评估他们对维生素D 400IU/天1个月的治疗反应，在冬季和早春期间，对维生素D 400 1U/天，连续1个月的前后进行了公开标记的比较。结果包括血钙、磷、白蛋白、25羟基维生素D[25(OH)D]、1，25二羟基维生素D[1，25(OH)(2)D]、甲状旁腺激素(PTH)和骨转换标志物(血清骨特异性碱性磷酸酶、骨钙素和尿N-端肽交联型胶原1[NTX])。膳食中维生素D的摄入量使用食物频率问卷进行评估。分析了42名受试者中的41人(平均年龄：8.9+/-1.2岁[SD])，其中20/41人(49%)维生素D不足。维生素D缺乏组有变老的趋势(9.2+/-1.0岁vs.8.5+/-1.3岁，p=0.06)和更早的青春期(Tanner 11：7/20 vs.Tanner II：1/21，p=0.02)。平均膳食维生素D摄入量为277(146IU/d)(n=41)。维生素D摄入量不足(200IU/天)的有16/41人(39%)，但维生素D不足组和维生素D充足组的膳食维生素D摄入量没有显著差异。
To determine the proportion of vitamin D insufficiency in 6- to 10-year-old preadolescent African-American children residing in Pittsburgh, Pennsylvania and to estimate their therapeutic response to vitamin D 400 IU/day for 1-month, an open-label pre- and post-comparison of vitamin D status following vitamin D 400 1U daily for 1 month during winter and early spring was conducted. Outcomes included serum calcium, phosphorus, albumin, 25 hydroxyvitamin D [25(OH)D], 1, 25 dihydroxyvitamin D [1,25(OH)(2)D], parathyroid hormone (PTH), and markers of bone turnover (serum bone-specific alkaline phosphatase, osteocalcin, and urine n-telopeptide crosslinked collagen type 1 [NTX]). Dietary intake of vitamin D was assessed using a food frequency questionnaire. Forty-one of the 42 enrolled subjects (mean age: 8.9 +/- 1.2 yrs [SD]) were analyzed, and 20/41 (49%) were vitamin D insufficient. Vitamin D insufficient group had a suggestive trend of being older (9.2 +/- 1.0 years vs. 8.5 +/- 1.3 years, p = 0.06) and more pubertally advanced (Tanner 11: 7/20 vs. Tanner II: 1/21, p = 0.02). Mean dietary intake of vitamin D was 277 (146 IU/day (n = 41). Adequate intake for vitamin D (200 IU/day) was not met in 16/41 (39%); however, the dietary intake of vitamin D was not significantly different between the vitamin D insufficient and vitamin D sufficient groups.