Hemolytic-uremic syndrome in a six-year-old girl after a urinary tract infection with Shiga-toxin-producing Escherichia coli O103:H2.
Hemolytic-uremic syndrome in a six-year-old girl after a urinary tract infection with Shiga-toxin-producing Escherichia coli O103:H2.
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一名 6 岁女孩因产志贺毒素大肠杆菌 O103:H2 尿路感染而出现溶血尿毒症综合征。
DOI：
10.1056/nejm199608293350905
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Clausen,CR
中科院分区：
文献类型：
--
作者：
Tarr,PI;Fouser,LS;Stapleton,AE;Wilson,RA;Kim,HH;VaryJr,JC;Clausen,CR
在美国，儿童溶血性尿毒症综合征通常是胃肠道感染大肠杆菌（157:h7.1 - 3）引起的。据推测，从胃肠道吸收志贺毒素1、2或两者（以前称为志贺样毒素4）产生byE。大肠杆菌157:H7引起微血管病溶血性贫血，是内皮细胞损伤的结果。属于O157:H7以外血清型的大肠杆菌也可引起溶血性尿毒症综合征。然而，尽管这些微生物被认为是肠胃炎散发性病例或爆发的原因，但它们不被认为是溶血性尿毒症综合征的重要原因……
In the United States, the hemolytic–uremic syndrome of childhood typically follows gastrointestinal infection withEscherichia coliO157:H7.1–3It is presumed that the absorption from the gastrointestinal tract of Shiga toxins 1, 2, or both (formerly called Shiga-like toxins4) produced byE. coliO157:H7 causes microangiopathic hemolytic anemia as a result of endothelial-cell injury.5Shiga-toxin–producingE. colibelonging to serotypes other than O157:H7 can also cause the hemolytic–uremic syndrome.5,6However, even though such organisms have been implicated as causes of sporadic cases7or outbreaks8of gastroenteritis, they are not believed to be important causes of the hemolytic–uremic syndrome . . .