Synthesis and bioactivity of novel strobilurin derivatives containing the pyrrolidine-2,4-dione moiety
Synthesis and bioactivity of novel strobilurin derivatives containing the pyrrolidine-2,4-dione moiety
复制标题
含有吡咯烷-2,4-二酮部分的新型甲氧基丙烯酸酯衍生物的合成和生物活性
DOI：
10.1016/j.cclet.2013.10.007
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发表时间：
2014-01-01
影响因子：
9.1
通讯作者：
Yang, Chun-Long
中科院分区：
文献类型：
--
作者：
Lu, Gui-Hua;Chu, Hai-Bin;Yang, Chun-Long
（E）-2-（2-溴甲基）苯基）-3-甲氧基丙烯酸甲酯分别与取代的1-乙酰基吡咯烷-2，4-二酮和3-（1-羟氨基）亚乙基吡咯烷-2，4-二酮反应，合成了两个系列的含吡咯烷-2，4-二酮结构的β-甲氧基丙烯酸酯衍生物。目标化合物的结构经IR、H-1 NMR、C-13 NMR、MS和元素分析确证。对水稻纹枯病菌、灰葡萄孢菌和禾谷镰刀菌进行了杀菌活性评价。生物活性测定结果表明，这些化合物具有明显的杀菌活性。(C)2013杨春龙Elsevier B. V.代表中国化学会出版。All rights reserved.
(E)-Methyl-2-(2-(bromomethyl)phenyl)-3-methoxyacrylate was reacted with substituted 1-acetylpyrrolidine-2,4-diones and 3-(1-(hydroxylamino)ethylidene)pyrrolidine-2,4-diones respectively to synthesize two series of beta-methoxyacrylate derivatives containing the pyrrolidine-2,4-dione moiety. The structures of the targeted compounds were confirmed by IR, H-1 NMR, C-13 NMR, MS and elemental analysis. The fungicidal activity against Rhizoctonia solani, Botrytis cinerea and Fusarium graminearum was evaluated. The bioassay results demonstrated that these compounds showed visible fungicidal activity. (C) 2013 Chun-Long Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.