Relationship between elevated arterial stiffness and increased left ventricular mass in adolescents and young adults.
Relationship between elevated arterial stiffness and increased left ventricular mass in adolescents and young adults.
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DOI：
10.1016/j.jpeds.2010.12.020
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发表时间：
2011-05
影响因子：
5.1
通讯作者：
Kimball, Thomas R.
中科院分区：
文献类型：
--
作者：
Urbina, Elaine M.;Dolan, Lawrence M.;McCoy, Connie E.;Khoury, Philip R.;Daniels, Stephen R.;Kimball, Thomas R.
To determine whether arterial stiffness relates to left ventricular mass (LVM) in adolescents and young adults. Study design Demographic, anthropometric, laboratory, echo, carotid ultrasound and arterial stiffness were measured in 670 subjects 10–24 yrs (35% male, 62% non-Caucasian). Global stiffness index (GSI) was calculated from 5 measures of carotid stiffness, augmentation index, brachial distensibility and pulse wave velocity (1 point if ≥95th% for subjects with BMI<85th%). Stiff arteries (S=73) were defined as GSI ≥95th%. Differences between flexible (F=597) and S groups were evaluated by t-tests. Models were constructed to determine if GSI was an independent determinant of LVM index (LVM/ht2.7) or relative wall thickness (RWT). S group had more adverse CV risk factors, higher LVM index and RWT (p≤0.05) with a trend for abnormal cardiac geometry. Independent determinants of LVM index were higher GSI, age, BMI, SBP, HR, HbA1c, male sex, and sex-by-HR interaction (r2 = 0.52; p≤ 0.05). GSI was also an independent determinant of RWT. Increased arterial stiffness in adolescents and young adults is associated with LVM index independently of traditional CV risk factors. Screening for arterial stiffness may be useful to identify high risk adolescents and young adults.
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DOI：
10.1016/s0735-1097(03)00480-7
发表时间：
2003-06-18
影响因子：
24
作者：
de Divitiis, M;Pilla, C;Deanfield, J
通讯作者：
Deanfield, J
影响因子：
3.5
作者：
Lekakis, JP;Zakopoulos, NA;Mavrikakis, ME
通讯作者：
Mavrikakis, ME
影响因子：
5.4
作者：
Munakata, M;Sakuraba, J;Toyota, T
通讯作者：
Toyota, T
影响因子：
3.2
作者：
Hashimoto, Junichiro;Nichois, Wilmer W.;Imai, Yutaka
通讯作者：
Imai, Yutaka
影响因子：
37.8
作者：
Cruickshank, K;Riste, L;Gosling, RG
通讯作者：
Gosling, RG