THERMODYNAMIC ANALYSIS OF THE PERMEABILITY OF BIOLOGICAL MEMBRANES TO NON-ELECTROLYTES
THERMODYNAMIC ANALYSIS OF THE PERMEABILITY OF BIOLOGICAL MEMBRANES TO NON-ELECTROLYTES
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DOI：
10.1016/0006-3002(58)90330-5
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发表时间：
1958-01-01
期刊：
影响因子：
--
通讯作者：
KATCHALSKY, A
中科院分区：
文献类型：
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作者：
KEDEM, O;KATCHALSKY, A
传统的渗透率方程在生物膜研究中的应用往往会产生矛盾。结果表明，通常采用的基于溶质渗透系数和水渗透系数的方程不符合不可逆过程热力学的要求。的不一致性被删除的热力学处理，以下的方法Staverman，这导致一个三系数系统考虑到相互作用：溶质-溶剂，溶质-膜和溶剂-膜。这里推导的方程已被应用到各种渗透性的测量发现在文献中，如：重水渗透到动物细胞，血管的渗透性，plasma的阈值浓度和松弛实验与人工膜。它示出了如何从实验数据中导出相关系数，以及如何选择合适的条件，以获得所有所需的信息的膜的渗透性。指出了这些系数对阐明膜结构的意义。
The application of the conventional permeability equations to the study of biological membranes leads often to contradictions. It is shown that the equations generally used, based on two permeability coefficients[long dash]the solute permeability coefficient and the water permeability coefficient[long dash]are incompatible with the requirements of thermodynamics of irreversible processes. The inconsistencies are removed by a thermodynamic treatment, following the approach of Staverman, which leads to a three coefficient system taking into account the interactions: solute-solvent, solute-membrane and solvent-membrane. The equations derived here have been applied to various permeability measurements found in the literature, such as: the penetration of heavy water into animal cells, permeability of blood vessels, threshold concentration of plasmolysis and relaxation experiments with artificial membranes. It is shown how the pertinent coefficients may be derived from the experimental data and how to choose suitable conditions in order to obtain all the required information on the permeability of the membranes. The significance of these coefficients for the elucidation of membrane structure is pointed out.