Hu-ets-1 and Hu-ets-2 genes are transposed in acute leukemias with (4;11) and (8;21) translocations.
Hu-ets-1 and Hu-ets-2 genes are transposed in acute leukemias with (4;11) and (8;21) translocations.
复制标题
Hu-ets-1 和 Hu-ets-2 基因在急性白血病中发生（4;11）和（8;21）易位。
DOI：
10.1126/science.3941901
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Papas,TS
中科院分区：
文献类型：
--
作者：
Sacchi,N;Watson,DK;GuertsvanKessel,AH;Hagemeijer,A;Kersey,J;Drabkin,HD;Patterson,D;Papas,TS
鉴定v-ets基因的细胞同源物Hu-ets-1和Hu-ets-2的人类探针以及两组啮齿动物-人类细胞杂交体用于研究急性白血病中发生的特异性易位。发现humanets-1基因在t（4;11）（q21;23）中从11号染色体易位到4号染色体，这是代表骨髓/淋巴前体细胞扩增的白血病亚型的易位特征。类似地，humanets-2基因被发现在t（8;21）（q22;q22）中从21号染色体易位到8号染色体，这是一种在具有形态学M2的急性髓性白血病（AML-M2）患者中常见的非随机易位。这两个易位与表达不同的表达在正常淋巴细胞的fetsgene，提高了这些基因在这些白血病的发病机制中发挥作用的可能性。
Human probes identifying the cellular homologs of the v-etsgene, Hu-ets-1 and Hu-ets-2, and two panels of rodent-human cell hybrids were used to study specific translocations occurring in acute leukemias. The humanets-1 gene was found to translocate from chromosome 11 to 4 in the t(4;11)(q21;23), a translocation characteristic of a subtype of leukemia that represents the expansion of a myeloid/lymphoid precursor cell. Similarly, the humanets-2 gene was found to translocate from chromosome 21 to chromosome 8 in the t(8;21)(q22;q22), a nonrandom translocation commonly found in patients with acute myeloid leukemia with morphology M2 (AML-M2). Both translocations are associated with expression different from the expression in normal lymphoid cells ofetsgenes, raising the possibility that these genes play a role in the pathogenesis of these leukemias.