How the Epigenome Contributes to the Development of Psychiatric Disorders
How the Epigenome Contributes to the Development of Psychiatric Disorders
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DOI：
10.1002/dev.20424
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发表时间：
2010-05-01
影响因子：
2.2
通讯作者：
Kobor, Michael S.
中科院分区：
文献类型：
--
作者：
Bredy, Timothy W.;Sun, Yi E.;Kobor, Michael S.
表观遗传学通常是指细胞性状在不改变DNA序列的情况下建立和遗传的发育过程。细胞记忆的这些机制也协调了成人大脑中的基因表达，最近的证据表明，“表观基因组”代表了环境信号、基因组反应的激活、抑制和维持以及持续行为之间的关键接口。在此，我们回顾了目前关于表观基因组对精神疾病发展的贡献的知识状态。(C) 2010 Wiley期刊公司中国心理医学杂志，2010,31(2):331-342。
Epigenetics commonly refers to the developmental process by which cellular traits are established and inherited without a change in DNA sequence. These mechanisms of cellular memory also orchestrate gene expression in the adult brain and recent evidence suggests that the "epigenome' represents a critical interface between environmental signals, activation, repression and maintenance of genomic responses, and persistent behavior. We here review the current state of knowledge regarding the contribution of the epigenome toward the development of psychiatric disorders. (C) 2010 Wiley Periodicals, Inc. Dev Psychobiol 52: 331-342, 2010.