Correlation between the presence of high-risk human papillomaviruses and Id gene expression in Syrian women with cervical cancer
Correlation between the presence of high-risk human papillomaviruses and Id gene expression in Syrian women with cervical cancer
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DOI：
10.1111/j.1469-0691.2009.02774.x
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发表时间：
2010-03-01
影响因子：
14.2
通讯作者：
Al Moustafa, A-E.
中科院分区：
文献类型：
--
作者：
Darnel, A. D.;Wang, D.;Al Moustafa, A-E.
高危人乳头瘤病毒(HPV)感染被认为是浸润性宫颈癌的主要原因。先前报道的研究表明，在包括宫颈癌在内的几种人类癌症中，ID基因调控细胞的侵袭和转移。为探讨高危型人乳头状瘤病毒(HPV)与人类子宫颈癌ID基因的相关性，采用聚合酶链式反应和组织芯片技术，对44例叙利亚宫颈癌患者进行了高危型HPV感染及其与ID基因表达的相关性研究。这项研究表明，在42例(95%)代表浸润性宫颈癌的样本中存在高危HPV，叙利亚妇女中最常见的高危HPV类型为33、16、18、45、52、58、35、51和31。此外，在大多数浸润性宫颈癌组织中，高危HPV的E6癌蛋白的表达与ID-1的过度表达有关，而与ID-2、ID-3或ID-4的过度表达无关。这些数据表明，高危HPV可以通过ID-1调节促进人类宫颈癌的进展。
P>Infection by high-risk human papillomaviruses (HPVs) is considered to be the central cause of invasive cervical cancer. Previously reported studies have shown that Id genes regulate cell invasion and metastasis in several human carcinomas including cervical cancer. In order to investigate the correlation between high-risk HPVs and Id genes in human cervical cancer, the presence of high-risk HPVs and their association with Id gene expression was examined using PCR methods and tissue microarray analyses in a cohort of 44 cervical cancer patients from Syria. This study showed that high-risk HPVs were present in 42 samples (95%) that represent invasive cervical cancers and that the most frequent high-risk HPV types in Syrian women were 33, 16, 18, 45, 52, 58, 35, 51 and 31. Furthermore, the expression of E6 oncoprotein of high-risk HPVs was found to correlate with overexpression of Id-1, but not of Id-2, Id-3 or Id-4 in the majority of invasive cervical cancer tissue samples. These data suggest that high-risk HPVs can enhance the progression of human cervical cancer through Id-1 regulation.