Blockade of the Tonic Hindlimb Extensor Component of Maximal Electroshock and Pentylenetetrazol‐Induced Seizures by Drugs Acting on Muscle and Muscle Spindle Systems: A Perspective on Method
Blockade of the Tonic Hindlimb Extensor Component of Maximal Electroshock and Pentylenetetrazol‐Induced Seizures by Drugs Acting on Muscle and Muscle Spindle Systems: A Perspective on Method
复制标题
作用于肌肉和肌梭系统的药物对最大电击和戊四唑引起的癫痫发作的强直后肢伸肌成分的阻断：方法的视角
作者：
A. Raines;C. Helke;M. Iadarola;L. Britton;Rebecca J. Anderson
在最大电击癫痫发作试验中，C-28'882-Ba（一种肌梭抑制剂）、氯丙嗪（一种梭动驱动抑制剂）和加拉胺（一种神经肌肉阻断药）可阻断强直性后肢伸展（THE）。这些药物还阻断了大剂量戊四唑产生的THE。丹曲林（一种肌肉收缩拮抗剂）和 MI-65-S（一种肌梭抑制剂）可显着延迟 THE。数据表明，THE 的阻断可能在多个位点上起作用，并且可能不是“抗惊厥”作用的表现。
Blockade of tonic hindlimb extension (THE) in the maximal electroshock seizure test was demonstrated for C‐28 ‘882‐Ba, a muscle spindle suppressant, chlorpromazine, a depressant of fusimotor drive, and gallamine, a neuromuscular blocking drug. These agents also blocked THE produced by very large doses of pentylenetetrazol. Dantrolene, a muscle contraction antagonist, and MI‐65‐S, a muscle spindle suppressant, significantly delayed THE. The data indicate that blockade of THE may be effected at a multiplicity of loci and may not be an expression of an “anticonvulsant” effect.