Carbon monoxide: present and future indications for a medical gas.
Carbon monoxide: present and future indications for a medical gas.
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DOI：
10.3904/kjim.2013.28.2.123
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Choi AM
中科院分区：
文献类型：
--
作者：
Ryter SW;Choi AM
气态分子在分子医学作为实验和临床治疗方面继续具有新的前景。低分子量气体一氧化碳 (CO) 和类似的气态分子（例如 H2S、一氧化氮）已被认为是炎症性疾病的潜在吸入疗法。高浓度时，CO 具有有毒吸入危险，是空气污染的常见成分。 CO 也作为血红素加氧酶催化的血红素降解产物而内源产生。 CO 与血红蛋白紧密结合，导致低氧血症并减少高浓度组织的氧气输送。在生理浓度下，CO可能作为信号转导分子在调节神经和血管功能以及细胞稳态中发挥内源性作用。 CO 已被证明在炎症、急性肺损伤、败血症、缺血/再灌注损伤和器官移植的临床前动物模型中可作为有效的抗炎剂。这种气体的其他实验适应症包括肺纤维化、肺动脉高压、代谢性疾病和先兆子痫。化学释放 CO 的化合物的开发构成了一种新颖的 CO 输送药物方法，并在脓毒症模型中显示出有效性。当前和即将进行的临床评估将确定这种气体作为人类疾病治疗剂的有用性。
Gaseous molecules continue to hold new promise in molecular medicine as experimental and clinical therapeutics. The low molecular weight gas carbon monoxide (CO), and similar gaseous molecules (e.g., H2S, nitric oxide) have been implicated as potential inhalation therapies in inflammatory diseases. At high concentration, CO represents a toxic inhalation hazard, and is a common component of air pollution. CO is also produced endogenously as a product of heme degradation catalyzed by heme oxygenase enzymes. CO binds avidly to hemoglobin, causing hypoxemia and decreased oxygen delivery to tissues at high concentrations. At physiological concentrations, CO may have endogenous roles as a signal transduction molecule in the regulation of neural and vascular function and cellular homeostasis. CO has been demonstrated to act as an effective anti-inflammatory agent in preclinical animal models of inflammation, acute lung injury, sepsis, ischemia/reperfusion injury, and organ transplantation. Additional experimental indications for this gas include pulmonary fibrosis, pulmonary hypertension, metabolic diseases, and preeclampsia. The development of chemical CO releasing compounds constitutes a novel pharmaceutical approach to CO delivery with demonstrated effectiveness in sepsis models. Current and pending clinical evaluation will determine the usefulness of this gas as a therapeutic in human disease.
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DOI：
10.1165/rcmb.2006-0340tr
发表时间：
2007-02-01
影响因子：
6.4
作者：
Alam, Jawed;Cook, Julia L.
通讯作者：
Cook, Julia L.
影响因子：
6.2
作者：
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通讯作者：
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影响因子：
4.8
作者：
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影响因子：
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作者：
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通讯作者：
Smith, Graeme N.
影响因子：
15.9
作者：
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通讯作者：
BLAKEMORE, WS