Design of low temperature-responsive hydrogels used as a temperature indicator
Design of low temperature-responsive hydrogels used as a temperature indicator
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用作温度指示剂的低温响应水凝胶的设计
DOI：
10.1016/j.polymer.2019.04.052
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发表时间：
2019
期刊：
影响因子：
4.6
通讯作者：
Zheng Jie
中科院分区：
文献类型：
--
作者：
Tang Li;Gong Liang;Zhou Guiyin;Liu Lingyun;Zhang Dong;Tang Jianxin;Zheng Jie
开发高热敏性水凝胶，特别是在低温范围内，在各个领域具有广阔的应用前景。在此，我们使用简单的一锅法设计、合成并表征了三元共聚物聚（N-叔丁基丙烯酰胺-共-N-异丙基丙烯酰胺-共-丙烯酰胺）p（NTBAM-共-NIPAM-共-AM）水凝胶。 NTBAM 和 NIPAM 两种热响应单体与亲水性 AM 单体的共聚，旨在通过改变 NTBAM、NIPAM 和 AM 的浓度和摩尔比，将下临界溶液温度 (LCST) 的温度范围调整在 8°C 至 10°C 之间。在最佳条件下，当温度从 8°C 略微变化到 10°C 时，p(NTBAM-co-NIPAM-co-AM) 水凝胶表现出快速且大幅度的消溶胀，在 2 分钟内其原始尺寸减小了 21%。这种低温触发的消膨胀行为和可调节的 LCST 特性可能归因于不同网络组件之间的微妙相互作用及其与水的相互作用。由于温度敏感性高（~2°C）、体积消溶胀率大（90%）和温度响应范围低（8-10°C），我们进一步展示了原型水凝胶球致动器作为温度指示器来监测较小的温度引起的尺寸变化。这种p(NTBAM-co-NIPAM-co-AM)水凝胶的设计策略可普遍适用于其他不同形状和温度响应范围的热响应水凝胶，可用作包括疫苗储存和运输在内的许多应用的低温指示剂。
Development of highly thermo-sensitive hydrogels, particularly at a low-temperature range, has promising applications in diverse fields. Herein we designed, synthesized, and characterized tri-copolymer poly(N-tert-butyl acrylamide-co-N-isopropyl acrylamide-co-acrylamide) p(NTBAM-co-NIPAM-co-AM) hydrogels using a facile one-pot method. The copolymerization of two thermo-responsive monomers of NTBAM and NIPAM with hydrophilic AM monomers aimed to tune the temperature range of lower critical solution temperature (LCST) between 8°C and 10 °C by varying the concentrations and molar ratios of NTBAM, NIPAM, and AM. At optimal conditions, p(NTBAM-co-NIPAM-co-AM) hydrogels showed a rapid and large deswelling by reducing their original sizes by 21% in 2 min as temperature was slightly changed from 8 °C to 10 °C. Such low-temperature-triggered de-swelling behavior and tunable LCST property are likely attributed to delicate interplay between different network components and their interactions with water. Due to high temperature sensitivity (∼2 °C), large volume deswelling ratio (90%), and low temperature-responsive range (8–10 °C), we further demonstrated a prototype hydrogel ball actuator as temperature indicator to monitor minor temperature-induced size changes. The design strategy for this p(NTBAM-co-NIPAM-co-AM) hydrogel could be generally applicable to other thermo-responsive hydrogels with different shapes and temperature-responsive ranges, which could be used as low-temperature indicator for many applications including vaccine storage and transportation.