Testicular steroidogenesis in the aging brown Norway rat.
Testicular steroidogenesis in the aging brown Norway rat.
复制标题
DOI：
10.1002/j.1939-4640.1993.tb01663.x
复制
发表时间：
1993-03
影响因子：
--
通讯作者：
B. Zirkin;Rosemary Santulli;John D. Strandberg;William W. Wright;Larry L. Ewing
中科院分区：
文献类型：
--
作者：
B. Zirkin;Rosemary Santulli;John D. Strandberg;William W. Wright;Larry L. Ewing
在寻找雄性生殖道与年龄相关的变化的动物模型时，我们研究了年龄对挪威棕色大鼠的健康和睾丸类固醇生成活性的影响，并与斯普拉格-道利大鼠进行了比较。当在最大刺激促黄体生成激素的条件下进行体外灌注时，21-24月龄的Sprague-Dawley大鼠的睾丸和18-30月龄的Brown挪威大鼠的睾丸激素产生显着与年龄相关的减少。睾丸产生睾酮能力的下降反映在与年龄相关的血清睾酮和生精小管液内睾酮浓度的下降。与斯普拉格-道利大鼠相反，布朗挪威大鼠类固醇生成活性的变化并不伴随垂体腺瘤、肥胖或睾丸肿瘤的发生。加上它的寿命长，使得挪威布朗菌株成为一种非常有前途的睾丸衰老模型。
In seeking an animal model of age-associated changes in the male reproductive tract, we examined the effects of age on the health and testicular steroidogenic activity of the Brown Norway rat, with comparisons made to the Sprague-Dawley rat. When perfused in vitro under conditions of maximally stimulating luteinizing hormone significant age-associated reductions were seen in testosterone production by testes of Sprague-Dawley rats of 21-24 months of age and by testes of Brown Norway rats of 18-30 months of age. Decreases in the capacity of the testes to produce testosterone were reflected in age-associated decreases in both serum testosterone and in testosterone concentration within the seminiferous tubule fluid. In contrast to the Sprague-Dawley rat, changes in steroidogenic activity in the Brown Norway rat were not accompanied by the occurrence of pituitary adenomas, obesity, or testicular tumors. This along with its longevity, make the Brown Norway strain a highly promising model for testicular aging.