Nonabsorbed carbohydrate: effect on fecal pH in methane-excreting and nonexcreting individuals.
Nonabsorbed carbohydrate: effect on fecal pH in methane-excreting and nonexcreting individuals.
复制标题
未吸收的碳水化合物：对甲烷排泄和非排泄个体粪便 pH 值的影响。
DOI：
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发表时间：
1989
影响因子：
7.1
通讯作者：
J. Perman
中科院分区：
文献类型：
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作者：
J. Flick;J. Perman
为了确定吸收不良的碳水化合物对粪便 pH 值的酸化作用在甲烷排泄者和非排泄者之间是否不同，我们向 5 名 CH4 排泄者和 6 名 CH4 非排泄者施用吸收不良的二糖乳果糖。乳果糖，每天两次，每次 20 g，持续 1 周，与 CH4 排泄者相比，CH4 非排泄者的粪便 pH 值显着降低（5.38 +/- 0.66 vs 6.90 +/- 0.61，p 小于 0.01）。为了确定这一观察结果是否是由于细菌碳水化合物发酵产生的酸的差异所致，将每个受试者的粪便与乳果糖一起孵育。各组之间的体外产酸或产氢没有差异。我们得出的结论是，吸收不良的碳水化合物不能诱导 CH4 排泄者体内结肠酸化。相比之下，CH4 排泄者和非排泄者的体外粪便碳水化合物发酵相似。这些结果表明这两组在结肠对发酵产物的吸收方面存在差异。
To determine whether the acidifying effect of malabsorbed carbohydrate on fecal pH differed between methane-excreting and nonexcreting individuals, we administered the poorly absorbed disaccharide lactulose to five CH4 excretors and six CH4 nonexcretors. Lactulose, 20 g twice daily for 1 wk, significantly lowered fecal pH among CH4 nonexcretors as compared with CH4-excreting individuals (5.38 +/- 0.66 vs 6.90 +/- 0.61, p less than 0.01). To determine whether this observation was due to differences in acid production from bacterial carbohydrate fermentation, feces from each subject were incubated with lactulose. There were no differences in in vitro acid or hydrogen production between groups. We conclude that malabsorbed carbohydrate fails to induce in vivo colonic acidification in CH4 excretors. In contrast, in vitro fecal carbohydrate fermentation is similar among CH4 excretors and nonexcretors. These results suggest differences between these two groups in the colonic absorption of fermentation products.