Blood lipids, lipid-related measures, and the risk of atherosclerotic cardiovascular disease.
Blood lipids, lipid-related measures, and the risk of atherosclerotic cardiovascular disease.
复制标题
血脂、血脂相关指标以及动脉粥样硬化性心血管疾病的风险。
DOI：
10.1093/oxfordjournals.epirev.a036310
复制
发表时间：
1987
影响因子：
5.5
通讯作者：
Anderson,RA
中科院分区：
文献类型：
--
作者：
Wallace,RB;Anderson,RA
关于脂质和动脉粥样硬化的科学文献和研究数量庞大，令人生畏。在这篇综述中，我们只考虑了最近的研究选择人类动脉粥样硬化疾病的发病率和血脂水平，脂蛋白，载脂蛋白和其他脂质代谢的元素之间的流行病学关联。(Here除非另有说明，我们通常使用术语脂质来表示所有与血脂相关的化合物。此外，如本文所用，动脉粥样硬化疾病大体上与临床动脉粥样硬化疾病同义。）在了解脂质代谢和动脉粥样硬化和动脉粥样硬化性心血管疾病的生物学方面取得的巨大进展（1）现在才被转化为人类动脉粥样硬化风险的研究，但对这些进展的一般性评论超出了本报告的范围。最近发表了一份关于脂质-冠状动脉疾病相关性的临床和病理生物学方面的简明历史（2）。缩略语：HDL，高密度脂蛋白; LDL，低密度脂蛋白; VLDL，极低密度脂蛋白。
The volume of scientific literature and research on lipids and atherosclerosis is large and daunting. In this review, we consider only selected recent research on the epidemiologic association between rates of human atherosclerotic diseases and levels of blood lipids, lipoproteins, apolipoproteins, and other elements of lipid metabolism.(Here, we use the term lipids to familiarly represent all blood lipid-related compounds, unless otherwise noted. In addition, as used in this paper, atherosclerotic disease is by and large synonymous with clinical atherosclerotic disease.) The tremendous advances in understanding lipid metabolism and the biology of atherogenesis and atherosclerotic cardiovascular disease (1) are only now being translated into studies of human atherogenesis risk, but general review of these advances is beyond the scope of this presentation. A concise history of the clinical and pathobiologic aspects of the lipid-coronary disease association has recently been published (2).Abbreviations: HDL, high density lipoprotein; LDL, low density lipoprotein; VLDL, very low density lipoprotein.