Elevated levels of interleukin-1 beta (IL-1 beta) and IL-6 in serum and increased production of IL-1 beta mRNA in lymph nodes of patients with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome.
Elevated levels of interleukin-1 beta (IL-1 beta) and IL-6 in serum and increased production of IL-1 beta mRNA in lymph nodes of patients with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome.
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多发性神经病、器官肿大、内分泌病、M 蛋白和皮肤变化 (POEMS) 综合征患者血清中白细胞介素 1 β (IL-1 β) 和 IL-6 水平升高，淋巴结中 IL-1 β mRNA 产生增加
DOI：
10.1182/blood.v83.9.2587.2587
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发表时间：
1994
期刊：
影响因子：
20.3
通讯作者：
J. Degos
中科院分区：
文献类型：
--
作者：
Romain K. Gherardi;Laurent Bélec;G. Fromont;M. Diviné;D. Malapert;Philippe Gaulard;J. Degos
为了评估细胞因子在多发性神经病变、器官肿大、内分泌病变、M蛋白和皮肤变化（POEMS）综合征发病机制中的可能意义，我们研究了5例连续的POEMS综合征患者，其中4例患有硬化性骨病变，4例患有多中心Castleman病。检测这些患者（13份血清样本）、多发性骨髓瘤患者（5份）和Waldenström巨球蛋白血症患者（5份）的血清白细胞介素-1 β (IL-1 β)和IL-6水平。对两例伴有Castleman病的POEMS综合征患者的淋巴结标本进行了相关mrna的原位杂交。POEMS综合征患者血清IL-1 β（13/13份样本）和IL-6（7/13份样本）水平升高。在其他患者中，血清IL-1 β未检测到或略有升高，IL-6在单个Waldenström巨球蛋白血症患者中升高。在这两名患者中，滤泡间隙中存在大量产生IL-1 β mrna的细胞，而产生IL-6 mrna的细胞很少。我们得出结论，POEMS综合征患者血清中IL-1 β和IL-6水平可能长期升高，淋巴结可能是IL-1 β过量产生的一个部位。这些结果与细胞因子介导POEMS综合征全身表现的假设一致。
To evaluate a possible implication of cytokines in the pathogenesis of polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (POEMS) syndrome, we studied five consecutive patients with this condition, of which four had sclerotic bone lesions and four had multicentric Castleman's disease. Interleukin-1 beta (IL-1 beta) and IL-6 serum levels were determined in these patients (13 serum samples) and in patients with multiple myeloma (5) and Waldenström's macroglobulinemia (5). In situ hybridization of the relevant mRNAs was performed on lymph node specimens of two patients with POEMS syndrome who had Castleman's disease. Elevated serum levels of IL-1 beta (13/13 samples), and IL-6 (7/13 samples) were found in patients with POEMS syndrome. In the other patients, serum IL-1 beta was undetectable or slightly increased and IL-6 was elevated in a single patient with Waldenström's macroglobulinemia. Abundant IL-1 beta mRNA-producing cells were present in interfollicular spaces in the two tested patients, while IL-6 mRNA-producing cells were rare. We conclude that IL-1 beta and IL-6 serum levels may be chronically elevated in patients with POEMS syndrome, and that lymph node may be one site of IL-1 beta overproduction. These results are in keeping with the hypothesis that cytokines mediate systemic manifestations of POEMS syndrome.