Differential shunting of EPSPs by action potentials
Differential shunting of EPSPs by action potentials
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DOI：
10.1126/science.291.5501.138
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发表时间：
2001-01-05
期刊：
影响因子：
56.9
通讯作者：
Stuart, GJ
中科院分区：
文献类型：
--
作者：
Häusser, M;Major, G;Stuart, GJ
神经元编码信息并通过动作电位进行通信，这些动作电位是在突触事件的总和之后产生的。通常认为，动作电位完全重置膜电位，允许另一轮突触整合开始。我们在这里表明，电导潜在的动作电位的行为，而不是作为一个变量重置突触整合。这种重置的强度是细胞类型特异性的，并且取决于突触输入的动力学、位置和定时。因此，远端突触。以及由N-甲基-D-天冬氨酸受体激活介导的输入，可以不成比例地促进动作电位放电期间的突触整合。
Neurons encode information and communicate via action potentials, which are generated following the summation of synaptic events. It is commonly assumed that action potentials reset the membrane potential completely, allowing another round of synaptic integration to begin. We show here that the conductances underlying the action potential act instead as a variable reset of synaptic integration. The strength of this reset is cell type-specific and depends on the kinetics, Location, and timing of the synaptic input. As a consequence, distal synapses. as well as inputs mediated by N-methyl-D-aspartate receptor activation, can contribute disproportionately to synaptic integration during action potential firing.