Delayed alternation in adolescent and adult male and female rats.
Delayed alternation in adolescent and adult male and female rats.
复制标题
青少年和成年雄性和雌性大鼠的延迟交替。
DOI：
10.1002/dev.20543
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发表时间：
2011
影响因子：
2.2
通讯作者：
Juraska,JaniceM
中科院分区：
文献类型：
--
作者：
Koss,WendyA;Franklin,AndrewD;Juraska,JaniceM
一些物种的前额叶皮层在整个青春期持续发育，我们的实验室已经证明，在青春期，大鼠内侧前额叶皮层（mPFC）的神经元数量减少。本研究使用 PFC 依赖性任务（延迟交替任务）来检查两性大鼠中 mPFC 仍在成熟时的功能。与成人相比，青少年在 15 秒和 60 秒延迟期间存在缺陷，但在其他延迟（5、10、30 和 90 秒）时则没有。此外，青少年犯了更多持续性错误。任何一个年龄组的延迟都没有出现显着的性别差异；然而，在即时培训课程中，青春期男性比女性更快达到标准。这些结果表明，在青春期和成年期之间，mPFC 依赖性任务的表现有所改善。 © 2011 Wiley periodicals, Inc. Dev Psychobiol 53:724–731, 2011。
The prefrontal cortex continues to develop throughout adolescence in several species, and our laboratory has demonstrated that during adolescence there is a decrease in neurons in the rat medial prefrontal cortex (mPFC). A PFC‐dependent task, the delayed alternation task, was used in the present study to examine the function of the mPFC while it is still maturing in rats of both sexes. A deficit was found in adolescents when compared to adults during 15‐ and 60‐s delays but not at other delays (5, 10, 30, and 90 s). Furthermore, adolescents committed more perseverative errors. No significant sex differences occurred at any delay for either age group; however, in the no delay training sessions, adolescent males reached criterion faster than females. These results indicate that performance on a mPFC‐dependent task improves between adolescence and adulthood. © 2011 Wiley Periodicals, Inc. Dev Psychobiol 53:724–731, 2011.