Prenatal maternal cortisol levels and infant behavior during the first 5 months
Prenatal maternal cortisol levels and infant behavior during the first 5 months
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产前母体皮质醇水平与婴儿头 5 个月的行为
DOI：
10.1016/s0378-3782(03)00088-4
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发表时间：
2003-11-01
影响因子：
2.5
通讯作者：
Buitelaar, JK
中科院分区：
文献类型：
--
作者：
de Weerth, C;van Hees, Y;Buitelaar, JK
背景和目标：对动物和人类的研究提供了越来越多的证据，证明产前因素可能对发育产生长期影响。大多数人类研究都检查了产前压力对出生结果的影响（即怀孕时间较短，婴儿较小）。少数研究婴儿后期发育的研究发现，产前压力与更难相处的气质、行为/情感问题和运动/认知发育不良有关。在本文中，我们研究了妊娠晚期皮质醇水平和婴儿在出生后前5个月的行为之间的联系。研究设计和受试者：17位母亲和她们健康的足月婴儿参加了这项前瞻性纵向研究。母亲的皮质醇在妊娠后期测定。婴儿的行为在家里的一系列洗澡过程中被录像：在1，3，5，7，18和20周大的时候。母亲在产后7周和18周填写气质问卷（ICQ）。结果与结论：根据母亲怀孕后期的皮质醇值，婴儿被分为两组：产前皮质醇高组和低组。高皮质醇组新生儿的分娩有早于低皮质醇组的趋势。此外，行为观察显示，高产前皮质醇组表现出更多的哭泣，大惊小怪和消极的面部表情。支持这些发现的是，母亲关于气质的报告也显示这些婴儿有更困难的行为：他们在情绪和活动方面得分更高。婴儿之间的差异在最小的年龄（1 - 7周）最大。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
Background and aims: Research on both animals and humans is providing more and more evidence that prenatal factors can have long-term effects on development. Most human studies have examined the effects of prenatal stress on birth outcome (i.e. shorter pregnancies, smaller infants). The few studies that have looked at the infants' later development have found prenatal stress to be related to more difficult temperament, behavioral/emotional problems and poorer motor/cognitive development. In this paper, we have examined links between late pregnancy cortisol levels and infant behavior during the first 5 months of life. Study design and subjects: Seventeen mothers and their healthy, full-term infants participated in this prospective, longitudinal study. The mothers' cortisol was determined in late pregnancy. The infants' behavior was videotaped during a series of bath sessions at the home: at 1, 3, 5, 7, 18 and 20 weeks of age. The mothers filled in temperament questionnaires (ICQ) in postnatal weeks 7 and 18. Results and conclusions: The infants were divided into two groups based on their mothers' late pregnancy cortisol values: high and low prenatal cortisol groups. A trend was found for the high cortisol infants to be delivered earlier than the low cortisol group. Furthermore, the behavioral observations showed the higher prenatal cortisol group to display more crying, fussing and negative facial expressions. Supporting these findings, maternal reports on temperament also showed these infants to have more difficult behavior: they had higher scores on emotion and activity. The differences between the infants were strongest at the youngest ages (weeks 1 - 7). (C) 2003 Elsevier Ireland Ltd. All rights reserved.