Clinicopathological significance and prognostic value of LRP16 expression in colorectal carcinoma.
Clinicopathological significance and prognostic value of LRP16 expression in colorectal carcinoma.
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DOI：
10.3748/wjg.v16.i13.1644
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发表时间：
2010-04
影响因子：
4.3
通讯作者：
H. Xi;P. Zhao;W. Han
中科院分区：
文献类型：
--
作者：
H. Xi;P. Zhao;W. Han
目的探讨白血病相关蛋白16 （leukemia related protein 16, LRP16）在结直肠癌中的表达，并分析其与临床病理特征及预后的关系。方法对201例结直肠癌和60例远端正常粘膜进行LRP16的免疫组化检测。复习病历并进行临床病理分析。结果201例大肠癌中有117例，60例远端正常黏膜中有21例检测到LRP16表达。LRP16在癌组织中的表达明显高于正常组织（chi(2) = 9.999, P = 0.002）。LRP16蛋白在I、II期癌中表达率为43.3%(52/120)，在III、IV期癌中表达率为80.2% (65/81)（chi(2) =27.088, P = 0.001）。LRP16表达与临床病理因素在肿瘤分化（P = 0.010）、肿瘤大小（P = 0.001）、浸润深度（P = 0.000）、远处转移（P = 0.027）等方面均有显著相关性。LRP16表达患者的中位生存时间（38.0 mo）与未表达患者的中位生存时间（105.0 mo）差异有统计学意义（Log rank = 41.455, P = 0.001）。多因素生存分析显示，LRP16表达与结直肠癌患者生存期缩短有显著相关性（Cox回归：P = 0.001，相对危险度= 2.082）。结论LRP16的表达与结直肠癌的分化程度、侵袭性、转移及预后有关。
AIM To explore the expression of leukemia related protein 16 (LRP16) in colorectal carcinoma, and analyze its correlation with clinicopathologic features and prognosis. METHODS Immunohistochemistry for LRP16 was performed in 201 cases of colorectal carcinoma and 60 cases of distal normal mucosa. Medical records were reviewed and clinicopathological analysis was performed. RESULTS LRP16 expression was detected in 117 of 201 cases of the colorectal carcinoma and in 21 cases of 60 distal normal mucosa. The expression of LRP16 in carcinoma was significantly higher than that in normal mucosa (chi(2) = 9.999, P = 0.002). LRP16 protein expression was found in 43.3% (52/120) of carcinoma at stage I and II, and 80.2% (65/81) of carcinoma at stage III and IV (chi(2) =27.088, P = 0.001). Correlation between LRP16 expression and clinicopathological factors was significant in differentiation (P = 0.010), tumor size (P = 0.001), infiltrative depth (P = 0.000) and distant metastasis (P = 0.027). The difference of median survival time between cancer patients with LRP16 expression (38.0 mo) and those without was statistically significant (105.0 mo, Log rank = 41.455, P = 0.001). The multivariate survival analysis revealed that LRP16 expression was correlated significantly (Cox's regression: P = 0.001, relative risk = 2.082) with shortened survival in the patients with colorectal cancer. CONCLUSION The expression of LRP16 is related to the degree of differentiation, invasiveness, metastasis and prognosis of colorectal carcinoma.