Hematopoietic stem cell trafficking - Regulated adhesion and attraction to bone marrow microenvironment
Hematopoietic stem cell trafficking - Regulated adhesion and attraction to bone marrow microenvironment
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DOI：
10.1196/annals.1402.086
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发表时间：
2007-01-01
期刊：
影响因子：
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通讯作者：
Frenette, Paul S.
中科院分区：
文献类型：
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作者：
Mendez-Ferrer, Simon;Frenette, Paul S.
造血作用优先发生在骨腔内，表明骨源性因子有助于血液形成。造血干细胞和祖细胞 (HSPC) 可以通过各种激动剂从骨髓实质动员至循环系统，这些激动剂的共同下游作用导致趋化因子 CXCL12 和介导迁移的粘附分子的表达或功能改变。粒细胞集落刺激因子 (G-CSF) 是最常用的动员 HSPC 的药物，可显着抑制成骨细胞功能。最近的研究表明，G-CSF 介导的抑制需要来自交感神经系统 (SNS) 的信号。这篇综述总结了被认为有助于干细胞迁移的新兴概念。
Hematopoiesis takes place preferentially within bone cavities, suggesting that bone-derived factors contribute to blood formation. Hematopoietic stem and progenitor cells (HSPCs) can be mobilized from the bone marrow parenchyma to the circulation by various agonists whose common downstream action leads to alteration in the expression or function of the chemokine CXCL12 and adhesion molecules mediating migration. Granulocyte colony-stimulating factor (G-CSF), the most prevalent drug used to mobilize HSPCs, dramatically suppresses osteoblast function. Recent studies suggest that G-CSF-mediated suppression requires signals from the sympathetic nervous system (SNS). This review summarizes emerging concepts thought to contribute to stem cell migration.