ELECTROPHYSIOLOGIC PROPERTIES AND NATURE OF VENTROLATERAL THALAMIC NUCLEUS NEURONS REACTIVE TO CONVERGING INPUTS OF PALEOCEREBELLAR AND NEOCEREBELLAR ORIGIN
ELECTROPHYSIOLOGIC PROPERTIES AND NATURE OF VENTROLATERAL THALAMIC NUCLEUS NEURONS REACTIVE TO CONVERGING INPUTS OF PALEOCEREBELLAR AND NEOCEREBELLAR ORIGIN
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DOI：
10.1016/0014-4886(86)90020-8
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发表时间：
1986-01-01
影响因子：
5.3
通讯作者：
PANTO, MR
中科院分区：
文献类型：
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作者：
BAVA, A;CICIRATA, F;PANTO, MR
在氯醛糖麻醉、电凝和人工呼吸的猫上进行了急性实验，以研究汇聚的小脑核(顶核、间位核、齿状核)传入丘脑腹外侧核单个神经元的一致性和功能特征，以及其汇聚神经元群体对刺激小脑核的反应性质(丘脑皮质中继或神经元间)。从细胞外和细胞旁记录的整体分析，我们得出结论：(1)古小脑冲动和新小脑冲动对丘脑腹外侧神经元的汇聚广泛存在，刺激小脑核对同一神经元既有兴奋性(单突触和多突触)效应，又有抑制(双突触和多突触)效应，(Ii)用细胞外记录技术测试的丘脑腹外侧神经元约有40%受到这些影响，用细胞外记录约有75%的丘脑腹外侧核神经元受到这些影响；(3)激活新小脑核输出主要产生兴奋性和兴奋性-抑制性反应模式，而激活古小脑核输出主要引起抑制性和兴奋性-抑制性反应模式；(4)汇聚的古新小脑神经元普遍存在于较前腹外侧核立体定向平面；和(5)从刺激躯体运动皮质区域获得的结果，腹外侧核汇聚单位中有很大一部分由丘脑皮质中继细胞组成。研究结果表明，在小脑-皮质通路丘脑中继核的水平上，姿势和自主动作之间可能存在整合，在编程、执行和纠正自主动作的过程中，中枢反馈和外周反馈之间存在交互作用。
Acute experiments were carried out in chloralose-anesthetized, curarized, and artificially ventilated cats to investigate the consistency and functional characteristics of converging cerebellar nuclear (fastigial, interpositus, dentate nuclei) inputs to single neurons of the ventrolateral thalamic nucleus, and the nature (thalamocortical relay or interneuronal) of its convergent neuronal population responsive to stimulation of the cerebellar nuclei. From unitary analysis of both extra- and juxtacellular recordings, we conclude that (i) convergence of paleo- and neocerebellar impulses on thalamic ventrolateral neurons occurs widely, and that both excitatory (mono- and polysynaptic) and inhibitory (di- and polysynaptic) effects are induced on the same neurons by cerebellar nuclei stimulation; (ii) these effects concern about 40% of the thalamic ventrolateral neuronal population tested using the extracellular recording technique and about 75% of the ventrolateral nucleus neurons tested using the juxtacellular recording; (iii) activation of neocerebellar nuclear outputs generates mainly excitatory and excitatory-inhibitory response patterns, whereas activation of the paleocerebellar nuclear outputs evokes predominantly inhibitory and excitatory-inhibitory response patterns; (iv) the convergent paleo- neocerebellar neurons are found commonly in the more anterior ventrolateral nucleus stereotaxic planes; and (v) from the results obtained by stimulation of the somatomotor cortical areas, a large proportion of the ventrolateral nucleus convergent units consists of thalamocortical relay cells. The results have implications for a possible integration between posture and voluntary movements at the level of the thalamic relay nucleus of the cerebellar-cortical pathway, and an interaction between central feedback and peripheral feedback in the programming, execution, and correction of voluntary movements.