Anxiety caused by a short-life hypnotic.
Anxiety caused by a short-life hypnotic.
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由短效催眠药引起的焦虑。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
I. Oswald
中科院分区：
文献类型：
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作者：
K. Morgan;I. Oswald
有选择地。显然，在缺乏T4的情况下，导致临床甲状腺功能亢进和血清浓度接近正常上限的T3替代方案可能并不总是足以抑制促甲状腺激素的分泌。这与Wahner和Gorman的研究结果一致，他们发现在接受T3替代疗法的甲状腺功能减退患者中，高于正常水平的血清T3浓度是达到正常血清促甲状腺激素水平所必需的。垂体内T3核受体的占据与促甲状腺激素分泌的抑制密切相关，这与其对循环T4的明显依赖形成对比。与其他组织相比，垂体局部细胞内T4单去碘的能力要高得多，从而为核受体提供T3提示T4对促甲状腺激素的反馈抑制有重要作用。因此，甲状腺滤泡癌或乳头状癌甲状腺切除术后应避免使用T3作为替代治疗，因为如果血清促甲状腺激素浓度没有充分降低，这些疾病的预后会更差
selectively. Apparently T3 replacement regimens that lead to clinical euthyroidism and serum concentrations close to the upper normal limit may not always be sufficient to suppress the secretion of thyroidstimulating hormone in the absence of T4. This agrees with the results of Wahner and Gorman,3 who found above normal serum concentrations of T3 to be necessary to achieve normal values of serum thyroidstimulating hormone in hypothyroid patients receiving T3 replacement therapy. The occupancy of nuclear receptors for T3 in the pituitary gland correlates well with the suppression of thyroid-stimulating hormone secretion,4 which contrasts with its apparent dependence on circulating T4. The difference may be explained by a much higher capacity of local intracellular monodeiodination of T4 in the pituitary gland compared with other tissues, providing T3 for the nuclear receptors.4 These observations indicate that T4 is important for the feedback suppression of thyroid-stimulating hormone. Therefore T3 should be avoided as replacement therapy after thyroidectomy for follicular or papillary cancer of the thyroid gland as the prognosis of these diseases is worse if the serum concentration of thyroid-stimulating hormone is not adequately reduced.5