Stimulation history dictates memory CD8 T cell phenotype: Implications for prime-boost vaccination
Stimulation history dictates memory CD8 T cell phenotype: Implications for prime-boost vaccination
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DOI：
10.4049/jimmunol.177.2.831
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发表时间：
2006-07-15
影响因子：
4.4
通讯作者：
Ahmed, Rafi
中科院分区：
文献类型：
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作者：
Masopust, David;Ha, Sang-Jun;Ahmed, Rafi
异源性初免-加强疫苗接种导致记忆T细胞频率增加。虽然这些再暴露于Ag的定量效应有很好的记录，但关于增强对记忆T细胞功能质量的影响知之甚少。为了解决这个关键问题，我们使用了三种不同类型的免疫方案，并研究了加强免疫如何影响记忆性CD 8 T细胞的功能和解剖位置。我们发现，记忆T细胞表型差异很大，这取决于免疫接种的数量和第二和第三响应导致在记忆CD 8 T细胞的产生，保留效应器样的属性，并显示出优先在非淋巴组织中的积累。这些结果表明，记忆分化与Ag经验的历史相关联，并且初免-加强免疫接种策略对记忆CD 8 T细胞质量和粘膜组织内的监测具有重要影响。
Heterologous prime-boost vaccination results in increased frequencies of memory T cells. Although these quantitative effects of reexposure to Ag are well documented, little is known about the impact of boosting on the functional qualities of memory T cells. To address this critical issue, we have used three different types of immunization regimens and examined how boosting effects the function and anatomic location of memory CD8 T cells. We found that memory T cell phenotype differed substantially depending on the number of immunizations and that secondary and tertiary responses resulted in the generation of memory CD8 T cells that retained effector-like properties and showed preferential accumulation in nonlymphoid tissues. These results show that memory differentiation is coupled to the history of Ag experience and that prime-boost vaccination strategies have important consequences on memory CD8 T cell quality and surveillance within mucosal tissues.