Emerging epidemic diseases of frogs in Britain are dependent on the source of ranavirus agent and the route of exposure
Emerging epidemic diseases of frogs in Britain are dependent on the source of ranavirus agent and the route of exposure
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DOI：
10.1017/s0950268806007679
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发表时间：
2007-10-01
影响因子：
4.2
通讯作者：
Bennett, P. M.
中科院分区：
文献类型：
--
作者：
Cunningham, A. A.;Hyatt, A. D.;Bennett, P. M.
进行了一系列传播研究，以调查在英国影响普通青蛙（蛙）的新出现的致命流行病综合征的病因学。这些综合征的特征是皮肤溃疡或全身出血，是在暴露于病变匀浆或培养的蛙病毒后诱导的。从实验感染的青蛙中重新分离出蛙病毒符合科赫的假设。先前与类似病变相关的嗜水气单胞菌对疾病发展无显著影响。出乎意料的是，疾病的结果受到代理商的来源和暴露途径的影响，表明不同的组织嗜性和致病性（可能类似于RNA病毒种群中的准种）的不同的蛙病毒在英国常见的青蛙种群中循环。我们的研究结果证实，蛙病毒病已成为英国两栖动物死亡的一个重要原因。
A series of transmission studies was conducted to investigate the aetiology, or aetiologies, of emerging fatal epidemic disease syndromes affecting the common frog (Rana temporaria) in Britain. The syndromes, characterized by skin ulceration or systemic haemorrhages, were induced upon exposure to lesion homogenates or cultured ranavirus. The re-isolation of ranavirus frorn experimentally affected frogs fulfilled Koch's postulates. Aeromonas hydrophila, previously associated with similar lesions, was not significant to disease development. Unexpectedly, disease outcomes were influenced by both the source of agent and the route of exposure, indicating that different ranaviruses with different tissue tropisms and pathogeneses (possibly similar to quasi-species in RNA virus populations) are circulating in the British common frog population. Our findings confirm that ranavirus disease has emerged as an important cause of amphibian mortality in Britain.