Cytotoxic sterol derivatives from a marine sponge Homaxinella sp.
Cytotoxic sterol derivatives from a marine sponge Homaxinella sp.
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DOI：
10.1021/np0496690
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发表时间：
2005-03-01
影响因子：
5.1
通讯作者：
Jung, JH
中科院分区：
文献类型：
--
作者：
Mansoor, TA;Hong, J;Jung, JH
一种海洋海绵Homaxinella sp.的生物活性导向分级分离导致分离出三种新的（1-3）高度降解的甾醇和四种新的6-O-烷基化（6-9）甾醇，以及沿着已知的甾醇衍生物。降解的甾醇（1-5）属于门齿甾醇类，以前从海洋海绵Dictyonella incissa分离。主要通过NMR和MS光谱分析确定了新化合物的总体结构。并讨论了侧链的立体异构性与保留时间的关系。针对一组五种人实体瘤细胞系测试化合物，并且特别是降解的甾醇（1-4）显示出显著的细胞毒性。
A bioactivity-guided fractionation of a marine sponge Homaxinella sp. has led to the isolation of three new (1-3) highly degraded sterols and four new 6-O-alkylated (6-9) sterols, along with known sterol derivatives. The degraded sterols (1-5) belong to the class incisterols, previously isolated from the marine sponge Dictyonella incisa. Mainly NMR and MS spectroscopic analyses established the gross structures of the new compounds. The relationship between the stereoisomerism of the side chain and HPLC retention time has also been discussed. The compounds were tested against a panel of five human solid tumor cell lines, and especially the degraded sterols (1-4) displayed significant cytotoxicity.