Connectome organization is related to longitudinal changes in general functioning, symptoms and IQ in chronic schizophrenia
Connectome organization is related to longitudinal changes in general functioning, symptoms and IQ in chronic schizophrenia
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DOI：
10.1016/j.schres.2015.03.012
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发表时间：
2016-06-01
影响因子：
4.5
通讯作者：
van den Heuvel, M. P.
中科院分区：
文献类型：
--
作者：
Collin, G.;de Nijs, J.;van den Heuvel, M. P.
新出现的证据表明，精神分裂症涉及人类连接体宏观布线结构的广泛改变。最近在精神分裂症患者的未受影响的同胞中减弱的连接体改变的发现表明，改变的连接体组织可能与发展障碍的脆弱性有关，但它是否与疾病发作后的疾病进展有关目前尚不清楚。在这里，我们研究了连接体结构和纵向变化的一般功能，临床症状和智商在3年后的MRI评估在一组慢性精神分裂症患者之间的相互作用。对患者的影响进行了比较，连接体组织和亚临床症状和智商的健康对照组和精神分裂症患者的未受影响的兄弟姐妹之间的关联。分析患者样本揭示了结构连接之间的关系，特别是在中央“脑枢纽”和一般功能的进展性变化（p = 0.007），这表明枢纽连接更突出的损害可能预示着未来的功能下降。我们的研究结果进一步表明，受影响的局部连接体组织与总体PANSS症状的纵向增加（p = 0.013）和总智商的降低（p = 0.003）有关，与基线症状和智商无关。在对照组和兄弟姐妹中没有观察到显著的相关性，这表明患者的发现代表了持续疾病的影响，而不是正常的时间相关变化。总之，我们的研究结果表明连接体结构对精神分裂症的病程具有预测价值。(C)2015爱思唯尔B.V.保留所有权利。
Emerging evidence suggests schizophrenia to involve widespread alterations in the macroscale wiring architecture of the human connectome. Recent findings of attenuated connectome alterations in unaffected siblings of schizophrenia patients suggest that altered connectome organization may relate to the vulnerability to develop the disorder, but whether it relates to progression of illness after disease onset is currently unknown. Here, we examined the interaction between connectome structure and longitudinal changes in general functioning, clinical symptoms and IQ in the 3 years following MRI assessment in a group of chronically ill schizophrenia patients. Effects in patients were compared to associations between connectome organization and changes in subclinical symptoms and IQ in healthy controls and unaffected siblings of schizophrenia patients. Analyzing the patient sample revealed a relationship between structural connectivity-particularly among central 'brain hubs'-and progressive changes in general functioning (p = 0.007), suggesting that more prominent impairments of hub connectivity may herald future functional decline. Our findings further indicate that affected local connectome organization relates to longitudinal increases in overall PANSS symptoms (p = 0.013) and decreases in total IQ (p = 0.003), independent of baseline symptoms and IQ. No significant associations were observed in controls and siblings, suggesting that the findings in patients represent effects of ongoing illness, as opposed to normal time-related changes. In all, our findings suggest connectome structure to have predictive value for the course of illness in schizophrenia. (C) 2015 Elsevier B.V. All rights reserved.