Effect of sodium channel blocker (mexiletine) on pathological ectopic firing pattern in a rat chronic constriction nerve injury model
Effect of sodium channel blocker (mexiletine) on pathological ectopic firing pattern in a rat chronic constriction nerve injury model
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DOI：
10.1007/s00776-005-0892-x
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发表时间：
2005-05-01
影响因子：
1.7
通讯作者：
Atsuta, Y
中科院分区：
文献类型：
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作者：
Nakamura, S;Atsuta, Y
我们通过研究美西律对慢性压迫性神经损伤（CCI）模型中病理性异位放电模式的影响，研究了美西律作为钠通道阻滞剂对神经病理性疼痛的疗效。实验用60只雄性Wistar大鼠进行。CCI模型通过松弛结扎坐骨神经来创建。繁殖后7天。分析腓肠神经逆行记录异位放电的频率和类型以及逆行感觉神经诱发电位的振幅。CCI大鼠静脉注射生理盐水和美西律（5或15 mg/kg）。美沙芬显著抑制自发放电频率，一个开关放电模式，包括周期性爆发棘波和异位放电产生缺氧条件下。美西律不影响逆行感觉神经诱发电位A δ成分的幅值。美西律通过阻断神经损伤部位和背根神经节异常钠通道的活性而抑制异位放电，但不阻断神经传导。本研究提示美西律可用于治疗周围神经病变的神经性疼痛。
We studied the efficacy of mexiletine as a sodium channel blocker for neuropathic pain by investigating the effect of mexiletine on the pathological ectopic firing pattern in a chronic constriction nerve injury (CCI) model. The experiment was conducted with 60 male Wistar rats. The CCI model was created by loosely ligating the sciatic nerve. After breeding 7 days. the frequency and pattern of ectopic firing antidromically recorded from the sural nerve and the amplitude of antidromic sensory nerve-evoked potential were analyzed. The CCI rats were given an intravenous injection of normal saline and mexiletine (5 or15mg/kg). Mexiletine significantly suppressed spontaneous firing frequency, an on-off firing pattern that consisted of cyclic bursting spikes and ectopic firing generation under the hypoxic condition. Mexiletine did not influence the amplitude of A-delta component in the antidromic sensory nerve-evoked potential. Mexiletine suppressed ectopic firing by blocking activity of the abnormal sodium channel at the nerve-injured site and dorsal root ganglion without blocking nerve conduction. This study Suggests that mexiletine is useful for treating neuropathic pain in peripheral neuropathy.