Telomere length inversely correlates with pulse pressure and is highly familial
Telomere length inversely correlates with pulse pressure and is highly familial
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DOI：
10.1161/01.hyp.36.2.195
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发表时间：
2000-08-01
期刊：
影响因子：
8.3
通讯作者：
Aviv, A
中科院分区：
文献类型：
--
作者：
Jeanclos, E;Schork, NJ;Aviv, A
有证据表明，端粒，染色体的末端，在体外和体内充当细胞衰老的时钟。在工业化国家，脉压随着年龄的增长而上升，它可能是脉管系统生物老化的表型。因此，我们进行了一项双胞胎研究，调查端粒长度之间的关系，在白色血细胞和脉压，同时评估的作用，遗传因素在决定端粒长度。我们用Southern印迹法测定了49对来自丹麦双生子登记册的双胞胎的白色血细胞末端限制性片段（TRF）的平均长度，并评估了血压参数与TRF的关系。TRF长度与脉压呈负相关。TRF长度和脉压均具有高度家族性。我们的结论是，端粒长度，这是遗传控制下，可能发挥作用的机制，调节脉压，包括血管老化。
There is evidence that telomeres, the ends of chromosomes, serve as clocks that pace cellular aging in vitro and in vivo. In industrialized nations, pulse pressure rises with age, and it might serve as a phenotype of biological aging of the vasculature. We therefore conducted a twin study to investigate the relation between telomere length in white blood cells and pulse pressure while simultaneously assessing the role of genetic factors in determining telomere length. We measured by Southern blot analysis the mean length of the terminal restriction fragments (TRF) in white blood cells of 49 twin pairs from the Danish Twin Register and assessed the relations of blood pressure parameters with TRF. TRF length showed an inverse relation with pulse pressure. Both TRF length and pulse pressure were highly familial. We conclude that telomere length, which is under genetic control, might play a role in mechanisms that regulate pulse pressure, including vascular aging.