Safety and efficacy of omega-3 fatty acids in the nutrition of very low birth weight infants: soy oil and marine oil supplementation of formula.
Safety and efficacy of omega-3 fatty acids in the nutrition of very low birth weight infants: soy oil and marine oil supplementation of formula.
复制标题
omega-3 脂肪酸在极低出生体重婴儿营养中的安全性和功效：配方奶粉中的大豆油和海洋油补充。
DOI：
10.1016/s0022-3476(05)83144-0
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Tyson,J
中科院分区：
文献类型：
--
作者：
Uauy,R;Hoffman,DR;Birch,EE;Birch,DG;Jameson,DM;Tyson,J
由于配方奶粉喂养的早产儿可能存在ω3必需脂肪酸缺乏的风险，我们测试了补充豆油以提供α-亚麻酸或海洋油以提供与人乳水平相当的预制ω3长链多不饱和脂肪酸的实验配方奶粉。本报告探讨了补充豆油或豆油和海产品油的喂养配方奶粉对孕后30 ~ 57周极低出生体重儿的生长、临床耐受性、凝血试验结果、红细胞膜流动性变化以及维生素A和E血浆浓度的影响。“健康的”早产儿由母亲选择接受人乳，或随机选择接受提供有限ω3脂肪酸的商业即食液体配方奶粉，或补充大豆油或大豆油和海洋植物油的实验配方奶粉。本研究的结果表明，富含豆油或含有预先形成的ω3长链多不饱和脂肪酸的豆油和海产品油的配方奶粉不会导致健康极低出生体重早产儿的生长、凝血功能、红细胞膜流动性或维生素A或E水平异常。需要进行额外的研究，以评估在代表性早产儿人群中的安全性。
Because formula-fed preterm in fants may be at risk of ω3 essential fatty acid deficiency, we tested experimental formulas supplemented with soy oil to provide α-linolenic acid or marine oil to provide preformed ω3 long-chain polyunsaturated fatty acids at a level comparable to that of human milk. This report addresses the effect of feeding formula supplemented with soy oil or with soy and marine oils on growth, clinical tolerance, coagulation test results, changes in erythrocyte membrane fluidity, and plasma concentrations of vitamins A and E in very low birth weight infants from 30 to 57 weeks of postconceptional age. “Healthy” preterm infants were maternally selected to receive human milk or selected at random to receive commercial ready-to-feed liquid formula, which provided limited ω3 fatty acid, or experimental formulas supplemented with soy oil or-soy and marine oils. Results of this study indicate that formula enriched with soy oil or soy and marine oils containing preformed ω3 long-chain polyunsaturated fatty acids does not induce abnormalities in growth, clotting function, erythrocyte membrane fluidity, or vitamin A or E levels in healthy very low birth weight preterm infants. Additional studies to evaluate safety in a representative preterm population are required.