Cocaine-using substance abuse treatment patients with and without HIV respond well to contingency management treatment.
Cocaine-using substance abuse treatment patients with and without HIV respond well to contingency management treatment.
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DOI：
10.1016/j.jsat.2017.03.001
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发表时间：
2017-06
影响因子：
3.9
通讯作者：
Petry NM
中科院分区：
文献类型：
--
作者：
Burch AE;Rash CJ;Petry NM
艾滋病毒在有物质使用障碍的人中很常见，但相对较少的研究考察了艾滋病毒状况对药物滥用治疗反应的影响。这项二次分析比较了因使用可卡因而寻求治疗的患者与未使用艾滋病毒的患者在药物使用治疗结果方面的差异。主要治疗结果包括治疗保留、最长戒断时间和阴性样本百分比；这两种物质使用结果都反映了同时戒除可卡因、酒精和阿片类药物。参与者(N=432)参加了比较应急管理(CM)和标准护理的随机临床试验，其中32人(7%)报告艾滋病毒呈阳性。总体而言，CM改善了治疗保留时间(平均8.2周，标准护理条件下为6.0周)和最长禁欲时间(平均5.8周，标准护理条件下为2.8周)，但对阴性样本的百分比没有显著影响。HIV状况与治疗结果之间不存在主效应关系，与治疗条件之间也不存在交互作用。这些结果表明，无论HIV状态如何，CM在药物滥用治疗中都有好处。
HIV is common among individuals with substance use disorders, but relatively few studies have examined the impact of HIV status on response to substance abuse treatment. This secondary analysis compared patients seeking treatment for cocaine use with and without HIV in terms of substance use treatment outcomes. Primary treatment outcomes included treatment retention, longest duration of abstinence, and percent of negative samples; both substance use outcomes reflect abstinence from cocaine, alcohol and opioids concurrently. Participants (N=432) were enrolled in randomized clinical trials comparing contingency management (CM) to standard care, and 32 (7%) reported being positive for HIV. Overall, CM improved both treatment retention (average of 8.2 weeks compared to 6.0 weeks in the standard care condition) and longest duration of abstinence (average of 5.8 weeks compared to 2.8 weeks in the standard care condition), but did not have a significant effect on percent of negative samples. HIV status was not associated with treatment outcomes as a main effect, nor did it have an interaction effect with treatment condition. These results suggest a benefit of CM in substance abuse treatment irrespective of HIV status.