Enabling migration by moderation: YAP/TAZ are essential for persistent migration.
Enabling migration by moderation: YAP/TAZ are essential for persistent migration.
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通过审核启用迁移：YAP/TAZ 对于持久迁移至关重要。
DOI：
10.1083/jcb.201902035
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Wirtz,Denis
中科院分区：
文献类型：
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作者：
Nair,PrafulR;Wirtz,Denis
持续的细胞迁移在生理过程中起着至关重要的作用，但其潜在的调控机制仍不清楚。Mason等人（2019. 201806065）显示，雅普/TAZ限制细胞骨架张力，这对于持续的（但不是起始的）细胞迁移是必需的。这项研究的潜在意义范围从胚胎发育到转移。
Persistent cell migration plays a crucial role in physiological processes, but its underlying mechanisms of regulation remain unclear. Mason et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201806065) show that YAP/TAZ limit cytoskeletal tension, which is essential for persistent (but not initiation of) cell migration. Potential implications of this study range from embryonic development to metastasis.