Locus ceruleus region: Effects on behavior of cholinergic, noradrenergic, and opiate drugs injected intracerebrally into freely moving cats
Locus ceruleus region: Effects on behavior of cholinergic, noradrenergic, and opiate drugs injected intracerebrally into freely moving cats
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蓝斑区域：向自由活动的猫脑内注射胆碱能、去甲肾上腺素能和阿片类药物对行为的影响
DOI：
10.1016/0014-4886(80)90161-2
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发表时间：
1980
影响因子：
5.3
通讯作者：
P. V. Dongen
中科院分区：
文献类型：
--
作者：
P. V. Dongen
研究了猫蓝斑及其周围125个部位脑内注射少量胆碱能、去甲肾上腺素能和阿片类药物的行为学效应。发现了许多可能与不同区域有关的影响。卡巴胆碱引起的肌张力减弱与异相睡眠时的肌张力减弱相当;最有效的区域是脑桥中央尾侧核和蓝斑下区域。将卡巴胆碱注入脑桥中央口核会引起防御反应，如嘶嘶声、咆哮声和紊乱的发声。在被盖背外侧核附近注射卡巴胆碱引起排尿和排便。卡巴胆碱引起同向和逆向循环时，注射在该地区或附近的去甲肾上腺素含细胞体，这种循环可能不是由于NE细胞。将α-去甲肾上腺素能和阿片受体激动剂注入脑桥中央口侧核的蓝斑吻侧部分，引起行为失活。α-去甲肾上腺素能激动剂引起呕吐;最有效的区域是第四脑室。脑内注射纳洛酮在吗啡治疗的猫拮抗吗啡诱导的刻板行为和部分的行为障碍，它建议，这是由于NE细胞：一个足够的感觉运动协调依赖于一个完整的中央NE传输。蓝斑可能是位于脑内的交感神经核，其靶区广泛分布于中枢神经系统。
Behavioral effects of intracerebral injections of small amounts of cholinergic, noradrenergic, and opiate agents into 125 sites in and around the locus ceruleus of the cat were investigated. Many effects were found that could be related to different regions. Carbachol caused atonia comparable to the atonia during paradoxical sleep; the most effective regions were the nucleus pontis centralis caudalis and the subceruleus region. Carbachol injected into the nucleus pontis centralis oralis caused defense reactions like hissing and growling and disturbed vocalizations. Micturation and defecation were elicited by carbachol injected near the nucleus laterodorsalis tegmenti. Carbachol caused ipsiversive and contraversive circling when injected in or near the region of the norepinephrine-containing cell bodies; this circling was probably not due to the NE cells. α-Noradrenergic and opiate agonists injected into the part of the nucleus pontis centralis oralis just rostral to the locus ceruleus caused behavioral inactivation. α-Noradrenergic agonists caused vomiting; the most effective region was the fourth ventricle. Naloxone injected intracerebrally in morphine-treated cats antagonized the morphine-induced stereotyped behavior and part of the behavioral disturbance; it is suggested that this is due to the NE cells: An adequate sensorimotor coordination was dependent on an intact central NE transmission. It is suggested that the locus ceruleus acts as a sympathetic nucleus situated in the brain with extensive parts of the central nervous system as its target regions.