Biologic monitoring of exposure to environmental chemicals throughout the life stages: requirements and issues for consideration for the National Children's Study.
Biologic monitoring of exposure to environmental chemicals throughout the life stages: requirements and issues for consideration for the National Children's Study.
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DOI：
10.1289/ehp.7617
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发表时间：
2005-08
影响因子：
10.4
通讯作者：
中科院分区：
文献类型：
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接触的生物监测是评估环境接触的有用工具。可用于分析的基质包括血液、尿液、母乳、脂肪组织和唾液等。抽样可以分阶段进行，以代表关注的特定时间段：从父母双方，从三个孕期的每一个孕期的孕妇，在分娩期间和分娩后立即，从出生后的母亲，以及从孩子成长到21岁。用于生物监测的适当样本将取决于基质的可得性、特定接触或健康影响的关注时间段以及有待监测的不同类别的环境化学品。本文介绍了在国家儿童研究中评价的生命阶段生物监测可用的基质;每一类化学品接触评估的最佳生物基质，包括考虑替代基质;用于分析的分析方法，包括质量控制程序和成本较低的替代品;分析成本;最佳储存条件;以及在长期储存期间的化学和基质稳定性。
Biomonitoring of exposure is a useful tool for assessing environmental exposures. The matrices available for analyses include blood, urine, breast milk, adipose tissue, and saliva, among others. The sampling can be staged to represent the particular time period of concern: preconceptionally from both parents, from a pregnant woman during each of the three trimesters, during and immediately after childbirth, from the mother postnatally, and from the child as it develops to 21 years of age. The appropriate sample for biomonitoring will depend upon matrix availability, the time period of concern for a particular exposure or health effect, and the different classes of environmental chemicals to be monitored. This article describes the matrices available for biomonitoring during the life stages being evaluated in the National Children’s Study; the best biologic matrices for exposure assessment for each individual chemical class, including consideration of alternative matrices; the analytical methods used for analysis, including quality control procedures and less costly alternatives; the costs of analysis; optimal storage conditions; and chemical and matrix stability during long-term storage.