Convergent cholinergic neurons produce similar postsynaptic actions in Aplysia: implications for neural organization.
Convergent cholinergic neurons produce similar postsynaptic actions in Aplysia: implications for neural organization.
复制标题
海兔中会聚的胆碱能神经元产生类似的突触后作用：对神经组织的影响。
DOI：
10.1152/jn.1982.47.4.742
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发表时间：
1982
影响因子：
2.5
通讯作者：
Koester,J
中科院分区：
文献类型：
--
作者：
Segal,MM;Koester,J
A neuron can have more than one type of receptor to acetylcholine (ACh). For example, Wachtel and Kandel (54) found that neuron L7 in Aplysia has both excitatory (E) and fast inhibitory (IF) receptors to ACh. The E receptors depolarize by opening Na+ channels and the IF receptors hyperpolarize by opening Cl-channels (7). In addition to E and IF receptors, Kehoe (3 1) has found that there is a third type of cholinergic receptor in Aplysia that produces slow inhibition (IS). This inhibition is believed to be due to either an opening of K+ channels (3 1) or closing of Na+ channels (57). Kehoe (32) has found not only neurons with both IF and IS receptors, but also neurons with all three types of receptors’: E, IF, and IS. In this paper we describe experiments designed to test whether neurons can receive synapses from different cholinergic cells, with one cholinergic cell activating selectively one type of ACh receptor and another cholinergic cell activating selectively a different type of ACh receptor on the same postsynaptic neuron. In other words, we were searching for a case in which a postsynaptic neuron, when it concentrates receptors at synapses, segregates different types of ACh
