Probiotics, prebiotics, and the host microbiome: the science of translation
Probiotics, prebiotics, and the host microbiome: the science of translation
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DOI：
10.1111/nyas.12303
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Sanders, Mary Ellen
中科院分区：
文献类型：
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作者：
Petschow, Bryon;Dore, Joel;Sanders, Mary Ellen
我们对人类微生物群落结构和功能的理解的最新进展对益生菌和益生元在促进人类健康方面的潜在作用具有影响。一组专家最近开会审查了微生物群/微生物组研究的最新进展，并讨论了益生菌和益生元开发的意义，主要是因为它们与通过肠道介导的作用有关。会议的目标是分享微生物群，微生物组，益生菌和益生元研究的最新进展，并在监管障碍，不断变化的医疗保健环境以及对各种健康主题的潜在影响的背景下讨论这些发现，包括肥胖和糖尿病的发展;生命早期暴露于抗生素对胃肠道（GI）微生物群的长期后果;乳糖不耐症;以及胃肠道微生物群与中枢神经系统之间的关系，对生活在发达国家和发展中国家的人们的抑郁症，认知，饱腹感和心理健康的影响。本报告概述了这些讨论。
Recent advances in our understanding of the community structure and function of the human microbiome have implications for the potential role of probiotics and prebiotics in promoting human health. A group of experts recently met to review the latest advances in microbiota/microbiome research and discuss the implications for development of probiotics and prebiotics, primarily as they relate to effects mediated via the intestine. The goals of the meeting were to share recent advances in research on the microbiota, microbiome, probiotics, and prebiotics, and to discuss these findings in the contexts of regulatory barriers, evolving healthcare environments, and potential effects on a variety of health topics, including the development of obesity and diabetes; the long-term consequences of exposure to antibiotics early in life to the gastrointestinal (GI) microbiota; lactose intolerance; and the relationship between the GI microbiota and the central nervous system, with implications for depression, cognition, satiety, and mental health for people living in developed and developing countries. This report provides an overview of these discussions.