Nerve growth factor in serum of children with systemic lupus erythematosus is correlated with disease activity
Nerve growth factor in serum of children with systemic lupus erythematosus is correlated with disease activity
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DOI：
10.1006/cyto.2002.1991
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发表时间：
2002-11-07
期刊：
影响因子：
3.8
通讯作者：
Lindholm, D
中科院分区：
文献类型：
--
作者：
Aalto, K;Korhonen, L;Lindholm, D
神经生长因子（NGF）是一种神经营养因子，在神经系统和外周器官中均有表达。NGF也存在于肥大细胞、B-和T-淋巴细胞中，并且可能在免疫细胞发育和分化中起作用。各种细胞因子已显示影响NGF表达，并且NGF在炎症和一些自身免疫性疾病中升高。在这里，我们研究了神经生长因子浓度的系统性红斑狼疮（SLE）的儿童患者血清中使用双位点酶联免疫吸附试验（ELISA）。我们进一步将神经生长因子的水平与疾病的炎症状态相关联。SLE患者血清NGF水平显著高于对照组（3346 vs 627 pg/ml）。SLE活动性与血清NGF水平有相关性。结果表明，NGF在儿童SLE中升高，并且水平与疾病活动相关。目前的结果表明，神经生长因子可能在SLE的发病机制中发挥作用，并可能在评估疾病的进程和概述药物治疗的预后价值。(C)2002爱思唯尔科技有限公司。保留所有权利。
Nerve growth factor (NGF) is a neurotrophic factor, which is expressed both in the nervous system and in peripheral organs. NGF is also present in mast cells, and in B- and T-lymphocytes, and may play a role in the immune cell development and differentiation. Various cytokines have been shown to affect NGF expression, and NGF is elevated in inflammation and in some autoimmune diseases. Here we have studied NGF concentrations in serum of pediatric patients with systemic lupus erythematosus (SLE) using a two-site enzyme-linked immunosorbent assay (ELISA). We have further correlated the levels of NGF to the inflammatory state of the disease. The mean value of serum NGF in SLE patients was significantly increased compared with controls (3346 vs 627 pg/ml). There was a correlation between the activity of SLE and the levels of NGF. The results show that NGF is elevated in childhood SLE and that the levels are correlated with disease activity. The present results suggest that NGF may play a role in the pathogenesis of SLE and may have a prognostic value in evaluating the course of the disease and in outlining the medication. (C) 2002 Elsevier Science Ltd. All rights reserved.