Taurine improves obesity-induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages
Taurine improves obesity-induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages
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DOI：
10.1002/mnfr.201300150
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发表时间：
2013-12-01
影响因子：
5.2
通讯作者：
Kawada, Teruo
中科院分区：
文献类型：
--
作者：
Lin, Shan;Hirai, Shizuka;Kawada, Teruo
范围
人们越来越接受慢性炎症是肥胖的一个特征。肥胖诱导的炎症引发巨噬细胞向脂肪组织的募集增强。根据其表型，巨噬细胞可被指定为促炎性M1巨噬细胞或抗炎性M2巨噬细胞。因此，我们研究了牛磺酸（一种在海鲜中含量丰富的含硫氨基酸）对肥胖相关炎症的影响。
方法和结果
在高脂饮食喂养的C57BL/6J小鼠中，牛磺酸治疗减少了巨噬细胞的浸润，并促进了脂肪组织中巨噬细胞的M2样表型。此外，牛磺酸降低了炎性细胞因子的产生，并抑制了饮食诱导的肥胖小鼠高血糖的发展。而且，涉及骨髓来源巨噬细胞的体外实验表明，牛磺酸治疗诱导了替代性M2巨噬细胞活化，其氯化物牛磺酸氯胺抑制了经典M1巨噬细胞活化。
结论
我们的研究结果表明，牛磺酸治疗减轻了巨噬细胞对脂肪组织的浸润并调节了巨噬细胞的表型，这表明牛磺酸是一种有价值的食物成分，有可能减轻脂肪组织中的慢性炎症并改善肥胖相关的胰岛素抵抗。
ScopeIt is increasingly accepted that chronic inflammation is a feature of obesity. Obesity-induced inflammation triggers enhanced recruitment of macrophages into the adipose tissue. Depending on their phenotype, macrophages can be designated either as pro-inflammatory M1 macrophages or anti-inflammatory M2 macrophages. We have therefore investigated the effects of taurine, a sulfated amino acid that is abundant in seafood, on obesity-related inflammation.Methods and resultsIn high-fat diet fed C57BL/6J mice, taurine treatment reduced the infiltration of macrophages and promoted an M2-like phenotype of macrophages in adipose tissues. In addition, taurine decreased the production of inflammatory cytokines, and suppressed the development of hyperglycemia in diet-induced obese mice. Moreover, in vitro experiments that involved bone marrow derived macrophages indicated that taurine treatment induced alternative M2 macrophage activation, and its chloride, taurine chloramines, inhibited classical M1 macrophage activation.ConclusionOur findings indicate that taurine treatment attenuates the infiltration of adipose tissue by macrophages and modulates the phenotype of macrophages, which suggest that taurine is a valuable food constituent with a potential to attenuate chronic inflammation in adipose tissue and improve obesity-related insulin resistance.